Aminoguanidine prevents ototoxicity induced by cisplatin in rats

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dc.authoridKIZILAY, Ahmet/0000-0003-3048-6489;
dc.authorwosidKALCIOGLU, Mahmut Tayyar/I-5884-2013
dc.authorwosidKIZILAY, Ahmet/ABI-8293-2020
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.contributor.authorIraz, M
dc.contributor.authorKalcioglu, MT
dc.contributor.authorKizilay, A
dc.contributor.authorKaratas, E
dc.date.accessioned2024-08-04T20:14:55Z
dc.date.available2024-08-04T20:14:55Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCisplatin (CDDP) is one of the most potent antineoplastic drugs, but its therapeutic use is limited by side effects such as ototoxicity. This study tested the effect of aminoguanidine (AG), a specific inhibitor of inducible nitric oxide synthase, on CDDP ototoxicity. Female Wistar albino rats were randomly assigned to 4 groups: saline controls (n=7), CDDP (n=7), CDDP plus AG (n=7), and AG (n=7). Rats in the CDDP group received a single injection of cisplatin (16 mg/kg, ip). Rats in the CDDP plus AG group received aminoguanidine (20 mg/kg, ip) twice daily on the day before and on 5 consecutive days after a single injection of CDDP (16 mg/kg, ip). Rats in the AG group received aminoguanidine (20 mg/kg, ip) twice daily for 6 days. Distortion product otoacoustic emissions (DPOAEs) were elicited from the control and experimental animals utilizing a standard commercial otoacoustic emissions apparatus. DPOAEs were measured in the rats on day 0, prior to any drug administration, and on day 5. The initial baseline distortion product diagrams (DPgram) and input/output (I/O) function measurements gave similar results in all 4 groups. On day 5, there was significant deterioration of the DPgrams and I/O functions in the CDDP group; no significant changes of DPgrams and I/O functions were observed on day 5 in the other 3 groups. The median amplitudes of DPgrams and I/O functions revealed significant differences between the CDDP group and the other 3 groups. These results suggest that AG had a preventive effect against CDDP ototoxicity. In summary, this study indicates that AG prevents the cochlear dysfunction and hearing loss induced in rats by a single dose of CDDP.en_US
dc.identifier.endpage335en_US
dc.identifier.issn0091-7370
dc.identifier.issn1550-8080
dc.identifier.issue3en_US
dc.identifier.pmid16081592en_US
dc.identifier.scopus2-s2.0-23844446045en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://hdl.handle.net/11616/94061
dc.identifier.volume35en_US
dc.identifier.wosWOS:000231112500016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Clinical Scientistsen_US
dc.relation.ispartofAnnals of Clinical and Laboratory Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectototoxicityen_US
dc.subjectcisplatinen_US
dc.subjectaminoguanidineen_US
dc.subjectotoacoustic emissionsen_US
dc.titleAminoguanidine prevents ototoxicity induced by cisplatin in ratsen_US
dc.typeArticleen_US

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