Investigation of serum minimal inhibitory concentrations of some benzimidazole, imidazole and benzothiazole derivatives and their effects on liver and renal functions

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dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridCetinkaya, Bekir/0000-0002-4551-8650
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.contributor.authorDurmaz, R
dc.contributor.authorKöroglu, M
dc.contributor.authorKüçükbay, H
dc.contributor.authorTemel, I
dc.contributor.authorÖzer, MK
dc.contributor.authorRefiq, M
dc.contributor.authorÇetinkaya, E
dc.date.accessioned2024-08-04T20:13:32Z
dc.date.available2024-08-04T20:13:32Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn previous studies many benzimidazole, imidazole and benzothiazole derivatives had been synthesized and their antimicrobial activities were tasted in vitro conditions. Four of these compounds showed minimal inhibitory concentrations (MIC) of 5-25 mu g/ml against standard strains and clinical isolates. In order to determine whether these four compounds can be used for therapeutic purpose, their serum MIC values and side effects on hepatic and renal functions were determined. Different concentrations of the compounds were tested on Wistar rats. Compound 1 was administered orally, intramuscularly and intravenously; compounds 2, 3 and 4 were given orally and intramuscularly. Blood samples were taken 4 and 24 h after administration of the compounds. Serum MIC Values were investigated by bioassay and serum levels of biochemical parameters by autoanalyzer. None of the tested compounds showed antimicrobial activity at their serum concentrations. Although creatinine activity was found at normal levels in all experiments, compounds 1 and 2 caused a significant increase in blood urea nitrogen (BUN) level. The values of aspartate aminotransferase and/or alanine aminotransferase and/or alkaline phosphatase which are characteristic for liver function were generally found at high levels. According to these results, it can be concluded that the tested compounds caused damage in liver and biliary tracts without antimicrobial activity by their serum concentrations.en_US
dc.identifier.endpage1184en_US
dc.identifier.issn0004-4172
dc.identifier.issue12en_US
dc.identifier.pmid9893934en_US
dc.identifier.scopus2-s2.0-0344628870en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1179en_US
dc.identifier.urihttps://hdl.handle.net/11616/93682
dc.identifier.volume48en_US
dc.identifier.wosWOS:000077745600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung-Drug Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbenzimidazoles, antimicrobial activity, pharmacokineticsen_US
dc.subjectbenzothiazoles, antimicrobial activity, pharmacokineticsen_US
dc.subjectimidazoles, antimicrobial activity, pharmacokineticsen_US
dc.titleInvestigation of serum minimal inhibitory concentrations of some benzimidazole, imidazole and benzothiazole derivatives and their effects on liver and renal functionsen_US
dc.typeArticleen_US

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