Histopathologic effects of meconium on human umbilical artery and vein: In vitro study

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dc.authorscopusid6603116813
dc.authorscopusid7102893402
dc.authorscopusid6603441523
dc.authorscopusid35461855900
dc.authorscopusid7006486682
dc.authorscopusid6701786840
dc.contributor.authorKafkasli A.
dc.contributor.authorBelfort M.A.
dc.contributor.authorGiannina G.
dc.contributor.authorVedernikov Y.P.
dc.contributor.authorSchaffner D.L.
dc.contributor.authorPopek E.J.
dc.date.accessioned2024-08-04T20:02:26Z
dc.date.available2024-08-04T20:02:26Z
dc.date.issued1997
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine the histopathologic effects of meconium on human umbilical artery and vein. Methods: Umbilical cords from six patients with uncomplicated, singleton, term gestations were obtained immediately after delivery. One centimeter segments from each cord were flushed, isolated, placed in either modified Krebs solution alone or modified Krebs solution with various concentrations (1%, 10%, or 25%) of fresh meconium, and then incubated at pH 7.2, temperature 37°C, PCO2 50-55 mmHg, PO2 40-45 mmHg for 1, 6, 12, or 24 h. The specimens were then fixed, stained, and examined under light microscopy. Results: Umbilical arteries exhibited focal vacuolation of the endothelium after exposure of the cord to meconium. Umbilical veins revealed: 1) endothelial loss proportionate to the meconium concentration at all intervals (P < 0.05), 2) increased density or focal absence of the internal elastic lamina, and 3) focal loss of myocyte nuclei. Rare nonpigmented macrophages and increased mast cells were identified in the Wharton's jelly. Conclusions: Exposure to meconium in vitro results in histopathologic changes in the umbilical artery and vein. © 1997 Wiley-Liss, Inc.en_US
dc.identifier.doi10.3109/14767059709162021
dc.identifier.endpage361en_US
dc.identifier.issn1476-7058
dc.identifier.issue6en_US
dc.identifier.pmid9438220en_US
dc.identifier.scopus2-s2.0-0031441909en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.3109/14767059709162021
dc.identifier.urihttps://hdl.handle.net/11616/91688
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherParthenon Publishing Group Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMeconiumen_US
dc.subjectTerm gestationsen_US
dc.subjectUmbilical vesselsen_US
dc.titleHistopathologic effects of meconium on human umbilical artery and vein: In vitro studyen_US
dc.typeArticleen_US

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