The Insertion allele of angiotensin converting enzyme increases the risk for coronary artery ectasia

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dc.contributor.authorTekedereli, Ibrahim
dc.contributor.authorKara, Murat
dc.contributor.authorDagli, Necati
dc.contributor.authorGurevin, Mehmet Sait
dc.contributor.authorKobat, Mehmet Ali
dc.date.accessioned2024-08-04T20:36:11Z
dc.date.available2024-08-04T20:36:11Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCoronary artery ectasia(CAE) is characterized by dilation of the coronary arteries, exceeding the 1.5-fold of normal adjacent segment in coronary angiography. A common polymorphism in the angiotensin converting enzyme (ACE) gene is insertion/deletion (I/D) polymorphism. The presence of D allele has been shown to be associated with higher blood ACE concentrations. One hundred CAE patients and the 100 healthy controls were enrolled in the study. The frequencies of DD, ID and II genotypes were 42, 48 and 10% for CAE patients, 65, 33 and 2% for healthy controls, respectively (p=0.0014). The allele frequencies for D and I allele were 0.815 and 0.185 for the control group and 0.660 and 0.340 for the patient group (p=0.0004). In conclusion, our data suggest that the I allele which represents lower ACE levels leads to a decrease in vascular tone and increase in the susceptibility to CAE.en_US
dc.identifier.endpage2859en_US
dc.identifier.issn1840-2291
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-84868109875en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2856en_US
dc.identifier.urihttps://hdl.handle.net/11616/95836
dc.identifier.volume6en_US
dc.identifier.wosWOS:000310816500035en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDrunpp-Sarajevoen_US
dc.relation.ispartofHealthmeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary artery ectasiaen_US
dc.subjectAngiotensin converting enzymeen_US
dc.subjectPolymorphismen_US
dc.titleThe Insertion allele of angiotensin converting enzyme increases the risk for coronary artery ectasiaen_US
dc.typeArticleen_US

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