Early portal vein thrombosis after pediatric liver transplantation: Assesment of risk factors

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dc.contributor.authorKarakas, Serdar
dc.contributor.authorŞahin, Tevfik Tolga
dc.contributor.authorSarıcı, Barış
dc.contributor.authorUsta, Sertaç
dc.contributor.authorKutlutürk, Koray
dc.contributor.authorVarol, Fatma İlknur
dc.contributor.authorSağlam, Kutay
dc.date.accessioned2024-08-04T19:42:43Z
dc.date.available2024-08-04T19:42:43Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Despite advancements in surgical techniques, early portal vein thrombosis (ePVT) continues to be one of the major complications of liver transplantation (LT) in pediatric age group. Possible risk factors are portal vein diameter < 5 mm, infancy, patient body weight < 10 kg and high graft recipient weight ratios (GRWR > 4.0). We retrospectively evaluated our records of pediatric LTs’ in terms of ePVT and possible risk factors determining development of this dreaded complication. Materials and Methods: Between January 2018 and January 2022, 228 LTs were performed for pediatric age (under the age of 18) group at Inonu University, Liver Trans- plantation Institute. Among these patients, 212 were eligible for the study. Patients with ePVT were defined as Portal Vein Thrombüs Group (PVTG) and patients with no Portal Vein thrombosis were defined in control group (CG). ePVT was described as detection of impeded portal venous outflow with imaging studies either perioperatively or within postoperative 3 days . Demographic, clinical and operative variables were retrospectively evaluated. Results: Among 212 LTs, 24 cases were complicated with ePVTs (11.3 %). Preoperative platelet counts, etiology of Budd-Chiari, postoperative hepatic artery thrombosis (HAT) and lower age were significantly higher for early PVT. In multivariate analysis, preop- erative platelet levels, etiology of Budd-Chiari and postoperative HAT were significantly higher for PVT. One and 5 years overall survivals (OS) for PVTG and CG were 50.0 % - 50.0 % and 69 % - 63 % respectively. No significant OS difference was observed despite much more patients were died in PVTG. Conclusion: High preoperative platelet counts, Budd-Chiari syndrome and postoperative HAT are predictive factors for ePVT. Anti-thrombotic prophylaxes can be considered in high-risk patients. Venous jump grafts seem to have no effect on ePVT. Despite PVT increases the mortality rates, it can be resolved easily with immediate reoperation.en_US
dc.identifier.doi10.5455/annalsmedres.2022.11.330
dc.identifier.endpage237en_US
dc.identifier.issn2636-7688
dc.identifier.issue2en_US
dc.identifier.startpage231en_US
dc.identifier.trdizinid1162263en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.11.330
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1162263
dc.identifier.urihttps://hdl.handle.net/11616/88603
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEarly portal vein thrombosis after pediatric liver transplantation: Assesment of risk factorsen_US
dc.typeArticleen_US

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