Mide Kanserlerinde Preoperatif Serum CEA, CA19-9 ve AFP Düzeylerinin Klinikopatolojik Faktörlerle Korelasyonu
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
Attribution 3.0 United States
Özet
Gastrik adenokarsinomlu hastalarda preoperatif serum karsinoemriyonik antijen (CEA), CA19-9 ve alfa-fetoprotein (AFP) düzeyi ile klinikopatolojik faktörlerin korelasyonunu araştırmak.
Metot: Gastrik adenokarsinom sebebiyle Ankara Yıldırım Beyazıt Eğitim Hastanesi 2. Cerrahi Kliniğinde ameliyat edilen 74 hastanın kayıtları retrospektif olarak incelendi. Hastaların preoperatif serum CEA, CA19-9, AFP düzeyleri ile bazı klinikopatolojik faktörler (tümör evresi, karaciğer metastazı, peritoneal
metastaz, asit varlığı, tümörün rezeke edilebilirliği) arasındaki korelasyon araştırıldı.
Bulgular: Hastaların preoperatif serum CEA, CA19-9, AFP pozitiflik oranları sırası ile %31.4, 30.3 ve 16.4 olarak bulundu. Hastaların 31’inde (%41,8) bir veya birden fazla tümör markırı yüksek iken, 8’inde (%13.1) üç markır da yüksek bulundu. Bu 8 hastanın 6’sı evre 4, 2’si evre 3 teki hastalardı.
Sonuç: Gastrik adenokarsinomlu hastalarda preoperatif serum CEA, CA19-9, AFP seviyelerinin ileri evreli, karaciğer metastazı yapmış, rezektabıl olmayan tümörlerde anlamlı oranda yüksek olduğu görüldü.
To investigate the correlation between preoperative serums CEA, CA19-9, and alphafetoprotein (AFP) levels and clinic pathological factors. Methods: The correlation between the records of pre-operative serum CEA, CA19-9, and alpha-fetoprotein levels and some clinic-pathological factors (tumor stage, liver metastasis, peritoneal metastasis, presence of ascites, unresectable tumors) of 74 patients with gastric adenocarcinoma operated in Ankara Yildirim Beyazit Education and Training Hospital 2nd Surgery Clinic was investigated. Results: Preoperative elevated serum CEA, CA19-9, and alpha-fetoprotein levels were found 31.4%, 30.3, and 16.4, respectively. While 31 (41.8%) out of 74 patients had one or more positive tumor markers, all three markers were found to be high in 8 patients (13.1%). Six of these patients were in stage 4, and the other two patients were in stage 3. Conclusion: Preoperative serum CEA, CA19-9, and alpha-fetoprotein levels were found high in patients with advanced stage, liver metastases, and unresectable gastric adenocarcinoma.
To investigate the correlation between preoperative serums CEA, CA19-9, and alphafetoprotein (AFP) levels and clinic pathological factors. Methods: The correlation between the records of pre-operative serum CEA, CA19-9, and alpha-fetoprotein levels and some clinic-pathological factors (tumor stage, liver metastasis, peritoneal metastasis, presence of ascites, unresectable tumors) of 74 patients with gastric adenocarcinoma operated in Ankara Yildirim Beyazit Education and Training Hospital 2nd Surgery Clinic was investigated. Results: Preoperative elevated serum CEA, CA19-9, and alpha-fetoprotein levels were found 31.4%, 30.3, and 16.4, respectively. While 31 (41.8%) out of 74 patients had one or more positive tumor markers, all three markers were found to be high in 8 patients (13.1%). Six of these patients were in stage 4, and the other two patients were in stage 3. Conclusion: Preoperative serum CEA, CA19-9, and alpha-fetoprotein levels were found high in patients with advanced stage, liver metastases, and unresectable gastric adenocarcinoma.
Açıklama
İnönü Üniversitesi Tıp Fakültesi Dergisi 15 (4) 233-237 (2008)
Anahtar Kelimeler
Gastrik Adenokarsinom, CEA, CA19-9, AFP, Klinikopatolojik Faktörler, Gastric Adenocarcinoma
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Dirican, Abuzer ;Ünal, Bülent ;Işık, Burak ; Sümer, Fatih ; Kayaalp, Cüneyt ;Aslan, İlhan ;İnönü Üniversitesi Tıp Fakültesi Dergisi 15 (4) 233-237 (2008)
