Ruthenium(II) complexes bearing benzimidazole-based N-heterocyclic carbene (NHC) ligands as potential antimicrobial, antioxidant, enzyme inhibition, and antiproliferative agents

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dc.authoridMansour, Lamjed/0000-0002-9415-9383
dc.authorwosidMansour, Lamjed/U-3028-2017
dc.contributor.authorBoubakri, Lamia
dc.contributor.authorChakchouk-Mtiba, Ahlem
dc.contributor.authorNaouali, Olfa
dc.contributor.authorMellouli, Lotfi
dc.contributor.authorMansour, Lamjed
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorYaser, Sedat
dc.date.accessioned2024-08-04T20:51:55Z
dc.date.available2024-08-04T20:51:55Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this work, new substituted benzimidazolium salts 2a-d having different groups on the side chain have been synthesized and reacted with Ag2O to produce Ag(I) N-heterocyclic carbene (NHC) complexes 3a-d. Ag(I)-NHC complexes were used as a carben transfer agents to synthesize ruthenium(II)-NHC complexes 4a-d. The structures of all compounds were characterized by H-1 NMR, C-13 NMR and FT-IR spectroscopies and elemental analysis. The IC50 values of these complexes were determined by MTT assay against MCF7, MDA-MB-231 and HF cancer cell lines. The lowest MIC values were obtained for two complexes, 4b and 4d. The Ru(II)-NHC complexes generally triggered stronger bacterial growth inhibition than the metal-free benzimidazolium cations. Enzymatic inhibition investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE) showed that 4b and 4d are the most potent inhibitors against AchE with an IC50 of 2.52 and 5.06 mu g mL(-1), respectively, and against TyrE with an IC50 of 19.88 and 24.95 mu g mL(-1), respectively. Antioxidant activity of the synthesized NHC ligands 2a-2d and their respective Ru(II)-NHC complexes 4a-4d was assessed by three different techniques: the 2.2-diphenyl-1-picrylhydrazyl (DPPH), the 2.2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging and the beta-carotene linoleic acid bleaching assay, showing that 4d has recorded an important antioxidant activity.en_US
dc.description.sponsorshipKing Saud University (Riyadh, Saudi Arabia) [RSP-2021/75]en_US
dc.description.sponsorshipThis work was supported by the Research Supporting Project (RSP-2021/75), King Saud University (Riyadh, Saudi Arabia).en_US
dc.identifier.doi10.1080/00958972.2022.2060745
dc.identifier.endpage667en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue5-6en_US
dc.identifier.scopus2-s2.0-85129321540en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage645en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2022.2060745
dc.identifier.urihttps://hdl.handle.net/11616/100629
dc.identifier.volume75en_US
dc.identifier.wosWOS:000782334200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Coordination Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological activityen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subject5en_US
dc.subject6-dimethylbenzimidazolium saltsen_US
dc.subjectruthenium(II) NHC complexesen_US
dc.subjectAg(I) NHC complexesen_US
dc.titleRuthenium(II) complexes bearing benzimidazole-based N-heterocyclic carbene (NHC) ligands as potential antimicrobial, antioxidant, enzyme inhibition, and antiproliferative agentsen_US
dc.typeArticleen_US

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