Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model

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dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridÖZEREN, MURAT/0000-0002-2672-6585;
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidÖZEREN, MURAT/N-7572-2015
dc.authorwosidGürses, İclal/AAH-8552-2021
dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.contributor.authorGurses, Iclal
dc.contributor.authorOzeren, Murat
dc.contributor.authorSerin, Meltem
dc.contributor.authorYucel, Neslihan
dc.contributor.authorErkal, Haldun Sukru
dc.date.accessioned2024-08-04T20:41:09Z
dc.date.available2024-08-04T20:41:09Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Melatonin is a hormone which is known to be a powerful cardioprotective agent due to its free radical-scavenging properties. This study was carried out to evaluate whether melatonin administration prior to irradiation would have a protective effect on cardiac histopathological changes in an experimental rat model. Methods: Rats were divided into four groups. Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. 50 mg/kg dose of melatonin were injected intraperitonally 15 min prior to radiation exposure. Analyses and assessments were performed 6 months after radiation exposure. Results: Severe myocardial fibrosis was observed prominently in three regions: the apex, tips of papillary muscles and adjacent to the atrioventricular valves. Inflammation was found to be more in irradiated groups. Increased inflammation and fibrosis were in concordance. The number of mast cells was found to be decreased in irradiated groups. Myocyte necrosis and fibrosis were diminished with melatonin while vasculitis was prevented. Conclusions: Elementary pathological lesions of radiation-induced heart disease (RIHD) are fibrosis, vascular damage, vasculitis and myocyte necrosis. Development of vasculitis was prevented by the use of melatonin. Fibrosis and necrosis were prominently decreased. Prevention of RIHD with the use of melatonin at the long term is encouraging according to the histopathological results. (C) 2014 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.prp.2014.08.006
dc.identifier.endpage871en_US
dc.identifier.issn0344-0338
dc.identifier.issue12en_US
dc.identifier.pmid25249491en_US
dc.identifier.scopus2-s2.0-84940166955en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage863en_US
dc.identifier.urihttps://doi.org/10.1016/j.prp.2014.08.006
dc.identifier.urihttps://hdl.handle.net/11616/96950
dc.identifier.volume210en_US
dc.identifier.wosWOS:000346454200014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofPathology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectHistopathologyen_US
dc.subjectRadiation-induced heart diseaseen_US
dc.subjectIrradiationen_US
dc.subjectRadioprotectionen_US
dc.titleHistopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat modelen_US
dc.typeArticleen_US

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