All-Trans-Retinoic Acid Attenuates Intestinal Injury in a Neonatal Rat Model of Necrotizing Enterocolitis

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dc.authoridOncel, Mehmet Yekta/0000-0003-0760-0773
dc.authoridUysal, Bulent/0000-0003-1254-9749
dc.authoridERDEVE, OMER/0000-0002-3193-0812
dc.authorwosidERDEVE, Omer/W-1480-2017
dc.authorwosidOncel, Mehmet Yekta/L-5664-2013
dc.contributor.authorOzdemir, Ramazan
dc.contributor.authorYurttutan, Sadik
dc.contributor.authorSari, Fatma Nur
dc.contributor.authorOncel, Mehmet Yekta
dc.contributor.authorErdeve, Omer
dc.contributor.authorUnverdi, Hatice Germen
dc.contributor.authorUysal, Bulent
dc.date.accessioned2024-08-04T20:37:32Z
dc.date.available2024-08-04T20:37:32Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Ischemia/reperfusion-induced intestinal injury is mediated by reactive oxygen species and inflammatory mediators. Objectives: This study was designed to evaluate whether all-trans-retinoic acid (ATRA) administration can attenuate intestinal injury and to analyze the antioxidant and anti-inflammatory effects of ATRA in a neonatal rat model of necrotizing enterocolitis (NEC). Methods: Twenty-nine Wistar albino rat pups were randomly divided into 3 groups: group 1 = control, group 2 = NEC and saline, and group 3 = NEC and ATRA treatment. NEC was induced by hyperosmolar enteral formula feeding and exposure to hypoxia after cold stress at +4 degrees C and oxygen. Pups in group 3 were injected intraperitoneally with ATRA (0.5 mg/kg body weight) once a day prior to each NEC procedure, beginning on postnatal day 1 and daily through postnatal day 4. The pups were killed on the 4th day and their intestinal tissues were harvested for biochemical and histopathological analysis. Results: Mucosal injury scores and intestinal malondialdehyde levels in group 2 were found to be significantly higher than other groups (p < 0.05). Intestinal superoxide dismutase and glutathione peroxidase activities in group 3 were significantly higher than group 2 (p = 0.04 and p = 0.04, respectively). Intestinal tissue tumor necrosis factor-alpha levels were significantly reduced with ATRA treatment in group 3 compared to group 2 (p < 0.001). Conclusions: It is likely that oxidative stress and inflammatory mediators contributed to the pathogenesis of NEC and that ATRA had a protective effect on intestinal injury through its anti-inflammatory and antioxidant properties. Copyright (c) 2013 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000350510
dc.identifier.endpage27en_US
dc.identifier.issn1661-7800
dc.identifier.issn1661-7819
dc.identifier.issue1en_US
dc.identifier.pmid23615357en_US
dc.identifier.scopus2-s2.0-84876457177en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage22en_US
dc.identifier.urihttps://doi.org/10.1159/000350510
dc.identifier.urihttps://hdl.handle.net/11616/96014
dc.identifier.volume104en_US
dc.identifier.wosWOS:000321442100005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofNeonatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNecrotizing enterocolitisen_US
dc.subjectAll-trans-retinoic aciden_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectTumor necrosis factor-alphaen_US
dc.titleAll-Trans-Retinoic Acid Attenuates Intestinal Injury in a Neonatal Rat Model of Necrotizing Enterocolitisen_US
dc.typeArticleen_US

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