The effects of acrylamide and Vitamin E administration during pregnancy on adult rats testis

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridErdemli, Erman/0000-0003-4596-7525
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridYigitcan, Birgul/0000-0002-7910-4595
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidErdemli, Erman/ABI-8193-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidYigitcan, Birgul/KUD-3587-2024
dc.contributor.authorErdemli, Zeynep
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorGul, Mehmet
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorBag, Harika Gozukara
dc.date.accessioned2024-08-04T20:45:53Z
dc.date.available2024-08-04T20:45:53Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThirty rats, with confirmed pregnancies by vaginal smear, were divided into five groups, each including six rats, as the Control, Corn Oil, Vitamin E, Acrylamide, Vitamin E + Acrylamide groups. The births were monitored on the 21st day to select the male rats, and the selected male rats were decapitated at the end of the 8th week. Oxidant-antioxidant parameters, serum hormone levels and histopathological examinations were performed on testis tissues of the rats. It was found that acrylamide (AA) negatively affected the serum hormone levels (Total Testosterone, Progesterone, FSH, LH, Estradiol), oxidant-antioxidant parameters in the tissues (MDA, GSH, NO, SOD, CAT, TAS, TOS) (p < 0.05) and the histological findings (the Johnson's score, seminiferous tubule diameter, histopathological images), and Vitamin E administration resulted with an increase in the total testosterone, progesterone, FSH, LH, GSH, TAS, NO, SOD, CAT levels (p < 0.05) and an improvement in histopathological findings. Currently, it is almost inevitable to be exposed to food-induced AA toxicity and such toxicity is likely to cause lifelong damage. It was concluded that Vitamin E was able to present a protective effect in the testis tissue against AA toxicity; however, further studies are necessary.en_US
dc.identifier.doi10.1111/and.13292
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue7en_US
dc.identifier.pmid30995698en_US
dc.identifier.scopus2-s2.0-85064564172en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.13292
dc.identifier.urihttps://hdl.handle.net/11616/98767
dc.identifier.volume51en_US
dc.identifier.wosWOS:000474289500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacrylamideen_US
dc.subjectinfertilityen_US
dc.subjectoxidative stressen_US
dc.subjectpregnancyen_US
dc.subjecttestisen_US
dc.subjectVitamin Een_US
dc.titleThe effects of acrylamide and Vitamin E administration during pregnancy on adult rats testisen_US
dc.typeArticleen_US

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