The acute effect of humic acid on ıron accumulation in rats

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dc.authorid1257en_US
dc.authorid100549en_US
dc.authorid116272en_US
dc.contributor.authorÇağın, Yasir Furkan
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorErdoğan, Mehmet Ali
dc.contributor.authorAtayan, Yahya
dc.contributor.authorEyol, Ergül
dc.contributor.authorBilgiç, Yılmaz
dc.contributor.authorSeçkin, Yüksel
dc.contributor.authorÇolak, Cemil
dc.date.accessioned2017-12-19T11:34:15Z
dc.date.available2017-12-19T11:34:15Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.descriptionBiol Trace Elem Res (2016) 171:145–155en_US
dc.description.abstractFree iron leads to the formation of pro-oxidant reactive oxygen species (ROS). Humic acids (HAs) enhance permeability of cellular wall and act as a chelator through electron transferring. This study was designed to test chelator effect of HA on iron as well as its anti-oxidant effect against the iron-induced hepatotoxicity and cardiotoxicity. The rats used were randomly divided into four groups (n = 8/group): group I (the control group); group II (the HA group), humic acid (562 mg/kg) was given over 10 days by oral gavage; group III (the iron group), iron III hydroxide polymaltose (250 mg/kg) was given over 10 days by intraperitoneal route; and group IV (the HA plus iron group), received the iron (similar to group II) plus humic acid (similar to those in groups II and III) group. Blood and two tissue samples both from liver and heart were obtained for biochemical and histopathological evaluations. Iron deposition, the iron-induced hepatotoxicity, and cardiotoxicity were demonstrated by histopathological and biochemical manner. However, no significant differences were observed in the serum biochemical values and the histopathological results among the iron and the HA plus iron groups in the liver tissue but not in the heart tissue. The protective effects of humic acid against iron-induced cardiotoxicity were shown but not against hepatotoxicity in our study.en_US
dc.identifier.citationÇağın, Y. F., Şahin, N., Polat, A., Erdoğan, M. A., Atayan, Y., Eyol, E., … Çolak, C. (2016). The Acute Effect Of Humic Acid On Iron Accumulation İn Rats. Biological Trace Element Research, 171(1), 145–155.en_US
dc.identifier.doi10.1007/s12011-015-0507-0en_US
dc.identifier.endpage155en_US
dc.identifier.issue0en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007%2Fs12011-015-0507-0.pdf
dc.identifier.urihttps://hdl.handle.net/11616/7905
dc.identifier.volume171en_US
dc.language.isoenen_US
dc.publisherBiological Trace Element Researchen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIronen_US
dc.subjectHepatotoxicityen_US
dc.subjectHumic aciden_US
dc.subjectChelationen_US
dc.subjectCardiotoxicityen_US
dc.titleThe acute effect of humic acid on ıron accumulation in ratsen_US
dc.typeArticleen_US

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