Comparison of low-dose dobutamine stress echocardiography and echocardiography during glucose-insulin-potassium infusion for detection of myocardial viability after anterior myocardial infarction

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dc.authorwosidIleri, Mehmet/A-6525-2018
dc.contributor.authorYetkin, E
dc.contributor.authorSenen, K
dc.contributor.authorIleri, M
dc.contributor.authorAtak, R
dc.contributor.authorTandogan, I
dc.contributor.authorYetkin, Ö
dc.contributor.authorKosar, F
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Low-dose dobutamine stress echocardiography (LDDSE) is one of the methods most used to assess myocardial viability. Glucose-insulin-potassium (GIK) infusion has been shown to increase contraction of the ischemic zone. The aim of this study was to compare LDDSE and echocardiography during GIK infusion for detection of myocardial viability. Methods Thirty-two patients who had first anterior myocardial infarction (MI) without previous MI were included in the study. Echocardiographic evaluation was carried out on the 7th +/- 2 days after MI. During continuous electrocardiographic, blood pressure and echocardiographic monitoring, an intravenous infusion of dobutamine (3 mug/kg body weight/min) was started with an infusion pump, continued for 5 min and then increased to 5 mug/kg/min and 10 mug/kg/min for another 5 min. The GIK protocol consisted of a fixed dose of insulin (100 muU/kg/h intravenously) and a variable glucose/potassium infusion rate. GIK echocardiography was done at baseline and after 60 min of GIK. The detected viable myocardium was defined as one or two scores decreasing in at least two adjacent abnormal segments during LDDSE and GIK echocardiography. Results Under resting conditions 225 segments (44%) were normokinetic, 21 segments (4%) dyskinetic, 117 segments (23%) akinetic and 149 segments (29%) hypokinetic. Viability was detected in 20% (57 segments) of the asynergic segments at baseline with GIK echocardiography and in 22% (62 segments) of those segments with LDDSE (P < 0.05). Left ventricular wall motion score index at baseline was 1.87 and it decreased significantly indicating improvement in left ventricular systolic function during both LDDSE and GIK echocardiography (P < 0.001, versus 1.75 and 1.76 respectively). The agreement between LDDSE and GIK echocardiography for detection of myocardial viability was 96%. Conclusion We have shown that GIK echocardiography is similar to LDDSE for detection of myocardial viability. With the support of further clinical studies GIK echocardiography could be used to detect myocardial viability after acute MI.en_US
dc.identifier.doi10.1097/00019501-200205000-00002
dc.identifier.endpage149en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue3en_US
dc.identifier.pmid12131017en_US
dc.identifier.scopus2-s2.0-0036305327en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.1097/00019501-200205000-00002
dc.identifier.urihttps://hdl.handle.net/11616/93402
dc.identifier.volume13en_US
dc.identifier.wosWOS:000176750900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmyocardial viabilityen_US
dc.subjectdobutamine stress echocardiographyen_US
dc.subjectglucose-insulin-potassiumen_US
dc.titleComparison of low-dose dobutamine stress echocardiography and echocardiography during glucose-insulin-potassium infusion for detection of myocardial viability after anterior myocardial infarctionen_US
dc.typeArticleen_US

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