The protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicity

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dc.authorscopusid6507504123
dc.authorscopusid7004559930
dc.authorscopusid6602664864
dc.authorscopusid57209542162
dc.authorscopusid7004914053
dc.authorscopusid7004152756
dc.contributor.authorAteş B.
dc.contributor.authorVardi N.
dc.contributor.authorParlakpinar H.
dc.contributor.authorKaraaslan M.G.
dc.contributor.authorYilmaz İ.
dc.contributor.authorErcal N.
dc.date.accessioned2024-08-04T20:00:56Z
dc.date.available2024-08-04T20:00:56Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractN-acetylcysteine amide (NACA) is a new antioxidant molecule with powerful radical scavenging properties. The aim of this study was to investigate neuroprotective effects of NACA against paraquat (PQ) toxicity in the midbrains of rats by using motor coordination tests and biochemical and histological analysis. Thirty adult Wistar albino rats were divided into three groups: Group 1: control (n = 10), Group 2: PQ (10 mg/kg) (n = 10), and Group 3: PQ (10 mg/kg) + NACA (100 mg/kg) (n = 10). NACA was administrated intraperitoneally 30 min before PQ injection. Performance was measured for a period of 28 days. The rotarod and accelerod tests were performed prior to and after the experimental period. After the experimental period, rats were sacrificed and midbrain tissues were removed. According to biochemical data, malondialdehyde levels exhibited a significant increase (P <0.05) when the PQ group was compared to the control group, whereas the NACA-treated group showed a significant decline (P < 0.05). The total glutathione levels (P < 0.01) and the glutathione peroxidase and butyrylcholinesterase activities (P < 0.05) in the NACA treatment group were significantly raised compared with the PQ group. The main finding in the rotarod and accelerod tests was that the PQ+NACA group had improved motor coordination functions, whereas the PQ group had lost motor coordination (P < 0.05). Our histological data were also outstanding and were consistent with biochemical and motor coordination results in terms of the protective role of NACA against PQ-induced neurotoxicity. © TÜBİTAKen_US
dc.description.sponsorshipİÜBAP-09en_US
dc.description.sponsorshipby a grant from the Scientific Research Fund of İnönü University (İÜBAP-09).en_US
dc.identifier.doi10.3906/kim-1706-8
dc.identifier.endpage49en_US
dc.identifier.issn1300-0527
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85065491979en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.3906/kim-1706-8
dc.identifier.urihttps://hdl.handle.net/11616/91129
dc.identifier.volume43en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTUBITAKen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlutathioneen_US
dc.subjectN-acetylcysteine amideen_US
dc.subjectNeuroprotectiveen_US
dc.subjectParaquaten_US
dc.subjectThiol antioxidanten_US
dc.titleThe protective effect of N-acetylcysteine amide against paraquat-induced neurotoxicityen_US
dc.typeArticleen_US

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