Evaluation of xanthine oxidase inhibitor properties on isoindoline-1,3-dion derivatives and calculation of interaction mechanism

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dc.authoridTASKIN TOK, Tugba/0000-0002-0064-8400
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridKISHALI, NURHAN/0000-0003-0262-1540
dc.authorwosidgündoğdu, özlem/AAP-4618-2020
dc.authorwosidTASKIN TOK, Tugba/A-8885-2016
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidNOMA, SAMIR/ABH-1773-2021
dc.contributor.authorGundugdu, Ozlem
dc.contributor.authorNoma, Samir Abbas Ali
dc.contributor.authorTaskin-Tok, Tugba
dc.contributor.authorAtes, Burhan
dc.contributor.authorKishali, Nurhan
dc.date.accessioned2024-08-04T20:47:02Z
dc.date.available2024-08-04T20:47:02Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to synthesis of isoindole-1,3(2H)-dione (Phthalimides) derivatives and to investigation the inhibition of xanthine oxidase (XO). In study, xanthine oxidase inhibitory activities of complexes were observed in the range from 7.15 to 22.56 mu M for isoindole-1,3-dione (2a-c and 3a-c). N-phenyl isoindole-1,3-dione derivatives (2c, 3c) showed better activity (almost two times) than the other two derivatives (N-methyl (2a, 3a), N-ethyl (2b, 3b). It means that phenyl ring (R) remarkably enhances the xanthine oxidase inhibitory effect of complexes. In the meantime, molecular docking studies of these compounds against XO were also investigated by providing the inhibitory efficiency and estimating the interaction mechanisms of isoindol-1,3-dion derivatives with XO. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipAtaturk University [2014/178, FBG-2018-6476]en_US
dc.description.sponsorshipWe would like to thank Ataturk University (Project number: 2014/178), (Project number: FBG-2018-6476) for its financial support of this work. The numerical calculations reported in this study were performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources).en_US
dc.identifier.doi10.1016/j.molstruc.2019.127523
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85076242836en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2019.127523
dc.identifier.urihttps://hdl.handle.net/11616/99097
dc.identifier.volume1204en_US
dc.identifier.wosWOS:000508216300028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIsoindoline-1,3-dioneen_US
dc.subjectPhthalimideen_US
dc.subjectXanthine oxidaseen_US
dc.subjectMolecular dockingen_US
dc.subjectBiological activityen_US
dc.titleEvaluation of xanthine oxidase inhibitor properties on isoindoline-1,3-dion derivatives and calculation of interaction mechanismen_US
dc.typeArticleen_US

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