The Novel Synthesized Pyridazinone Derivates Had the Antiproliferative and Apoptotic Effects in SHSY5Y and HEP3B Cancer Cell Line

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dc.authoridSözen, Mustafa Mert/0000-0002-1672-2206
dc.authoridAcar, Ceren/0000-0003-1842-9203
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridOzdemir, Zenyep/0000-0003-4559-2305
dc.authorwosidSözen, Mustafa Mert/E-7278-2011
dc.authorwosidAcar, Ceren/B-5758-2008
dc.authorwosidAcar, Ceren/M-2926-2019
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidOzdemir, Zenyep/AAJ-6384-2020
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Zeynep
dc.contributor.authorAcar, Ceren
dc.contributor.authorSozen, Mert
dc.contributor.authorBasak-Turkmen, Nese
dc.contributor.authorAyhan, Idris
dc.contributor.authorGozukara, Harika
dc.date.accessioned2024-08-04T20:44:26Z
dc.date.available2024-08-04T20:44:26Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Brain cancer (neuroblastoma) and liver cancer (hepatocellular carcinoma) are common cancer types among others worldwide which do not have a radical treatment and cure. Objective: In the current study, five novel pyridazinone derivates bearing benzelhydrazone moiety at second position were synthesized and evaluated for their cytotoxic activity against neuroblastoma and hepatocellular carcinoma (SHSY5Y and HEP3B) and human fibroblast (HF) cell lines. The aim of the current study is to identify antiproliferative activity of five novel pyridazinone derivates against neuroblastoma and hepatocellular carcinoma (SHSY5Y and HEP3B) and human fibroblast (HF) cell lines. Method: The compounds were synthesized by the reacting 6-[4-(phenyl/4-chlorophenyl)piperazine-1yl]-3(2H)-pyridazinone-2-yl acetohydrazide with benzaldehyde in ethanol. The in vitro antiproliferative activities were determined with MTT assay. Bax, Bcl-2 and Casp3 gene expression levels were detected with RT-PCR analyses. Results: The lowest IC50 was observed for compound 4 in SHSY5Y and HEP3B cells. Apoptosis increased in cancer cells which was shown by changes inBax, Bcl-2 and Casp3 gene expression levels with 1-5 compound therapy. Conclusion: Novel pyridazinone derivates might be promising agents as new chemotherapeutic candidates in brain and liver cancer.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of the Turkish Republic) [113S838]; TUBITAKen_US
dc.description.sponsorshipWe acknowledge the support of TUBITAK (Scientific and Technical Research Council of the Turkish Republic) under Grant 113S838. It is a great pleasure to thank TUBITAK for their financial support during our project.en_US
dc.identifier.doi10.2174/1570178614666170707154210
dc.identifier.endpage331en_US
dc.identifier.issn1570-1786
dc.identifier.issn1875-6255
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85045412804en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.2174/1570178614666170707154210
dc.identifier.urihttps://hdl.handle.net/11616/98242
dc.identifier.volume15en_US
dc.identifier.wosWOS:000427316400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofLetters in Organic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptotic effectsen_US
dc.subjectantitumoral effectsen_US
dc.subjectbrain canceren_US
dc.subjectcytotoxic effectsen_US
dc.subjectliver canceren_US
dc.subjectpyridazinoneen_US
dc.titleThe Novel Synthesized Pyridazinone Derivates Had the Antiproliferative and Apoptotic Effects in SHSY5Y and HEP3B Cancer Cell Lineen_US
dc.typeArticleen_US

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