Inflammatory parameters in gingival crevicular fluid and saliva of patients with celiac disease: a comparative analysis

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dc.contributor.authorSabanci, Arife
dc.contributor.authorKirmizigul, Omer Alperen
dc.contributor.authorOzgen, Nazmi
dc.contributor.authorSabanci, Halil Ibrahim
dc.contributor.authorKoc, Ahmet
dc.contributor.authorDisli, Faruk
dc.contributor.authorYildiz, Sedat
dc.date.accessioned2026-04-04T13:37:31Z
dc.date.available2026-04-04T13:37:31Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjective Celiac disease (CD) is an immune-mediated chronic enteropathy that causes chronic inflammation and has been found to cause oral health problems. The aim of this study was to compare the levels of the inflammatory markers calcium (Ca), caspase-1 and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) and saliva of patients with and without celiac disease. Methods A total of 60 participants were divided into two groups: patients with celiac disease on a gluten diet (C) (n = 30) and systemically healthy controls (H) (n = 30). Full-mouth periodontal measurements, including the gingival index (GI), plaque index (PI), bleeding on probing (BOP), and probing depth (PD), were recorded for all participants. Saliva and GCF samples were collected for analysis of the levels of TNF-alpha, Ca, and caspase-1 via enzyme-linked immunosorbent assay (ELISA). Results Salivary and GCF Ca, caspase-1, and TNF-alpha levels were not different between the two groups (p > 0.05). Conclusions Oral inflammatory profiles of celiac disease patients on a gluten-free diet show similarities with systemically healthy individuals.
dc.description.sponsorshipInonu University, Malatya, Turkiye Research Fund Grant [THD-2023-3335]
dc.description.sponsorshipThis study was supported by Inonu University, Malatya, Turkiye Research Fund Grant THD-2023-3335.
dc.identifier.doi10.1007/s00784-025-06622-9
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue11
dc.identifier.orcid0000-0001-5828-8949
dc.identifier.orcid0000-0002-0531-2746
dc.identifier.orcid0000-0002-7872-790X
dc.identifier.orcid0000-0003-3484-2137
dc.identifier.orcid0000-0003-3326-1293
dc.identifier.orcid0000-0003-4798-4548
dc.identifier.pmid41145949
dc.identifier.scopus2-s2.0-105019947403
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00784-025-06622-9
dc.identifier.urihttps://hdl.handle.net/11616/109882
dc.identifier.volume29
dc.identifier.wosWOS:001603252800002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectCeliac disease
dc.subjectGingival inflammation
dc.subjectTumor necrosis factor-alpha
dc.subjectCalcium
dc.subjectCaspase 1
dc.titleInflammatory parameters in gingival crevicular fluid and saliva of patients with celiac disease: a comparative analysis
dc.typeArticle

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