Melatonin as a free radical scavenger in experimental head trauma

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dc.authoridcirak, bayram/0000-0002-3946-0456
dc.contributor.authorCirak, B
dc.contributor.authorRousan, N
dc.contributor.authorKocak, A
dc.contributor.authorPalaoglu, O
dc.contributor.authorPalaoglu, S
dc.contributor.authorKilic, K
dc.date.accessioned2024-08-04T20:12:07Z
dc.date.available2024-08-04T20:12:07Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.descriptionEuropean Congress on Neurotrauma -- OCT, 1998 -- MAGDEBURG, GERMANYen_US
dc.description.abstractHead trauma causes two kinds of injury in the neural tissue. One is the primary injury which occurs at the time of impact. The other one is a secondary injury and is a progressive process. Free radicals are produced during oxidative reactions formed after trauma. They have been thought to be responsible in the mechanism of the secondary injury. Some studies have been conducted to demonstrate the role of free oxygen radicals in neuronal injury. The alterations in the free radical level during the early posttraumatic period and the effect of a free radical scavenger on these alterations have not been studied as a whole. We aimed to demonstrate the free oxygen radical level changes in the early posttraumatic period and the effect of melatonin, which is a potent free radical scavenger, on the early posttraumatic free radical level. A two-staged experimental head trauma study was designed. In stage one, post-traumatic free radical level changes were determined. In the second stage, the effect of melatonin on the free radical level changes in the post-traumatic period was studied. Two main groups of rats each divided into four subgroups were studied. Rats in one of the main groups underwent severe head trauma, and malondealdehyde (MDA) levels were measured in the contused cerebral tissue at different time points. Rats in the other main group also underwent the same type of trauma, and melatonin was injected intraperitoneally at different time points after trauma. The MDA level alteration in the tissue was determined after the injection of melatonin. The MDA level increased rapidly in the early posttraumatic period. But in time, it decreased in the groups with only trauma. In the melatonin-treated group, the MDA level decreased after the injection of melatonin, when injected in the early posttraumatic period, compared to the control and trauma groups. However, melatonin increased MDA to a higher level than in the groups with only trauma and the control group when injected later than 2 h after trauma. The MDA level increases in the very early posttraumatic period of cerebral trauma and decreases in time. Melatonin, which is the most potent endogenous free radical scavenger, when injected intraperitoneally to the cerebral traumatized rats in the very early posttraumatic period, causes a significant decrease in the MDA level. But, melatonin, when injected more than 2 h after trauma, increases the MDA level in experimental cerebral trauma in rats. Copyright (C) 2000 S. Karger AG, Basel.en_US
dc.description.sponsorshipBundesministerium Fur Bild Forschen_US
dc.identifier.doi10.1159/000028879
dc.identifier.endpage301en_US
dc.identifier.issn1016-2291
dc.identifier.issue6en_US
dc.identifier.pmid10702729en_US
dc.identifier.scopus2-s2.0-0033495507en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.1159/000028879
dc.identifier.urihttps://hdl.handle.net/11616/93199
dc.identifier.volume31en_US
dc.identifier.wosWOS:000085802600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPediatric Neurosurgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectexperimental head traumaen_US
dc.subjectfree radicalen_US
dc.subjectlipid peroxidationen_US
dc.subjectmalondealdehydeen_US
dc.subjectmelatoninen_US
dc.titleMelatonin as a free radical scavenger in experimental head traumaen_US
dc.typeConference Objecten_US

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