Systemic effects of H2S inhalation at human equivalent dose of pathologic halitosis on rats

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dc.authoridhocaoğlu, turgay peyami/0000-0002-0281-8928
dc.authoridözdemir, hakan/0000-0001-9550-1999
dc.authoridAydin, Murat/0000-0003-0030-8999
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authorwosidOzdemir, Hakan/AAG-3194-2021
dc.authorwosidhocaoğlu, turgay peyami/AAM-8349-2021
dc.authorwosidözdemir, hakan/IXE-1202-2023
dc.authorwosidAydin, Murat/HCI-8580-2022
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.contributor.authorYeler, Defne Yalcin
dc.contributor.authorAydin, Murat
dc.contributor.authorGul, Mehmet
dc.contributor.authorHocaoglu, Turgay
dc.contributor.authorOzdemir, Hakan
dc.contributor.authorKoraltan, Melike
dc.date.accessioned2024-08-04T20:43:15Z
dc.date.available2024-08-04T20:43:15Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: Halitosis is composed by hundreds of toxic gases. It is still not clear whether halitosis gases self-inhaled by halitosis patients cause side effects. The aim of the study was to investigate the effect of H2S inhalation at a low concentration (human equivalent dose of pathologic halitosis) on rats. Materials and methods: The threshold level of pathologic halitosis perceived by humans at 250ppb of H2S was converted to rat equivalent concentration (4.15ppm). In the experimental group, 8 rats were exposed to H2S via continuous inhalation but not the control rats. After 50 days, blood parameters were measured and tissue samples were obtained from the brain, kidney and liver and examined histopathologically to determine any systemic effect. Results: While aspartate transaminase, creatine kinase-MB and lactate dehydrogenase levels were found to be significantly elevated, carbondioxide and alkaline phosphatase were decreased in experimental rats. Other blood parameters were not changed significantly. Experimental rats lost weight and became anxious.Histopathological examination showed mononuclear inflammatory cell invasion in the portal areas, nuclear glycogen vacuoles in the parenchymal area, single-cell necrosis in a few foci, clear expansion in the central hepatic vein and sinusoids, hyperplasia in Kupffer cells and potential fibrous tissue expansion in the portal areas in the experimental rats. However, no considerable histologic damage was observed in the brain and kidney specimens. Conclusions: It can be concluded that H2S inhalation equivalent to pathologic halitosis producing level in humans may lead to systemic effects, particularly heart or liver damage in rats.en_US
dc.description.sponsorshipScientific Research Project Fund of Cumhuriyet University [Dis-106]en_US
dc.description.sponsorshipThis research study was supported by the Scientific Research Project Fund of Cumhuriyet University (Project ID: Dis-106).en_US
dc.identifier.doi10.1080/00016357.2017.1350992
dc.identifier.endpage523en_US
dc.identifier.issn0001-6357
dc.identifier.issn1502-3850
dc.identifier.issue7en_US
dc.identifier.pmid28693361en_US
dc.identifier.scopus2-s2.0-85023203112en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.1080/00016357.2017.1350992
dc.identifier.urihttps://hdl.handle.net/11616/97888
dc.identifier.volume75en_US
dc.identifier.wosWOS:000407925300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofActa Odontologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHalitosisen_US
dc.subjectintoxicationen_US
dc.subjectH2Sen_US
dc.subjectinhalationen_US
dc.titleSystemic effects of H2S inhalation at human equivalent dose of pathologic halitosis on ratsen_US
dc.typeArticleen_US

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