Urinary nitric oxide levels are increased and correlated with plasma concentrations in patients with Behcet's disease

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dc.authoridTürköz, Yusuf/0000-0001-5401-0720;
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidcekmen, mustafa baki/G-6122-2011
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.contributor.authorEvereklioglu, C
dc.contributor.authorÖzbek, E
dc.contributor.authorÇekmen, M
dc.contributor.authorMehmet, N
dc.contributor.authorDuygulu, F
dc.contributor.authorOzkiris, A
dc.contributor.authorÇalip, M
dc.date.accessioned2024-08-04T20:13:29Z
dc.date.available2024-08-04T20:13:29Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNitric oxide ( NO) is a free radical and serves many functions within the kidney. Excess NO causes glomerular injury. Behcet's disease (BD) is a systemic immunoinflammatory vasculitis, affecting every organ in the body including the kidneys ( subclinic glomerulonephritis). We investigated the role of urinary total nitrite levels (end product of NO) in BD and evaluated whether urinary concentrations were correlated with its plasma levels or disease activity. Thirty-six consecutive Behcet's patients (19 men, 17 women; 35.9 years), and 20 age- and sex-matched healthy control volunteers (12 men, eight women; 33.2 years) were divided into an active (n = 16) and inactive ( n = 20) period. Urinary and serum NO levels (mumol/mg urinary creatinine) were higher in BD patients (4.1 +/- 0.3) than control subjects (1.7 +/- 0.2; P < 0.001). Serum NO levels in Behcet's patients and control subjects were 51.3 +/- 9.8 and 21.7 +/- 7.3 mu mol/ L, respectively (P < 0.001). Active patients had higher urinary NO excretion (4.9 +/- 0.3) than inactive patients (3.3 +/- 0.3; P < 0.01). Urinary NO levels were correlated with its serum levels (r(2) = 0.69, P < 0.001). Higher urinary NO levels found in BD may be produced by the kidney as a result of an inflammatory stimulation. As excess NO is toxic to the tissues, increased NO levels may play a role in mediating subclinic glomerular injury of such patients. However, we could not determine the exact site(s) of NO synthesis by the kidney, such as the glomeruli, blood vessels and/or the tubular cells. Whatever the source, urinary NO levels may be used as a new activity marker in the diagnosis and follow up of BD by serial measurements.en_US
dc.identifier.doi10.1046/j.1440-1797.2003.00180.x
dc.identifier.endpage238en_US
dc.identifier.issn1320-5358
dc.identifier.issn1440-1797
dc.identifier.issue5en_US
dc.identifier.pmid15012709en_US
dc.identifier.scopus2-s2.0-0242490190en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://doi.org/10.1046/j.1440-1797.2003.00180.x
dc.identifier.urihttps://hdl.handle.net/11616/93651
dc.identifier.volume8en_US
dc.identifier.wosWOS:000185552900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectactivityen_US
dc.subjectBehcet's diseaseen_US
dc.subjectnitric oxideen_US
dc.subjecturineen_US
dc.titleUrinary nitric oxide levels are increased and correlated with plasma concentrations in patients with Behcet's diseaseen_US
dc.typeArticleen_US

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