The Effects of Cisplatin on the Kidney Metabolism: Role of Ginkgo Biloba Extract

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dc.authorscopusid7102711821
dc.authorscopusid6701534014
dc.authorscopusid6603836580
dc.authorscopusid6701808364
dc.authorscopusid7006625363
dc.contributor.authorYilmaz H.R.
dc.contributor.authorIşik B.
dc.contributor.authorGüleç M.
dc.contributor.authorSö?üt S.
dc.contributor.authorAkyol Ö.
dc.date.accessioned2024-08-04T20:01:12Z
dc.date.available2024-08-04T20:01:12Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to examine whether antitumour drug cisplatin affect the metabolism of the kidney and consequently causes kidney damage and, Ginkgo biloba extract prevents this damage in rats. The experimental groups were as follows: Control group, Cisplatin-treated group (Cisplatin), and a group treated with Cisplatin plus Ginkgo biloba extract (GBE). The Cisplatin and Cisplatin+GBE groups were treated intraperitoneally with a single dose of 7 mg/kg body weight sisplatin at 4th day of the treatment. GBE was administrated at a dose of 100 mg/kg body weight orally, three days before and seven days after the treatment with cisplatin in the cisplatin+GBE group. Kidney tissues were taken 7 day after the cisplatin administration. The activities of kidney hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH) and malate dehydrogenase (MDH) serum enzymes were determined in each sample. The results of the experiment demonstrated that HK, G6PD, LDH, and MDH activities were increased significantly in the cisplatin group compared with control group. HK and G6PD activities were increased significantly in the cisplatin group compared with control group. G6PD activity was increased significantly in the cisplatin+GBE group compared with cisplatin group, and LDH activity was decreased significantly in the cisplatin+GBE group compared with cisplatin group. From these results, it can be concluded that cisplatin may cause kidney damage through metabolic enzymes and, GBE may prevent damage caused by cisplatin.en_US
dc.identifier.endpage24en_US
dc.identifier.issn1301-8825
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-1842420530en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://hdl.handle.net/11616/91333
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTHOD - Turk Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectGBEen_US
dc.subjectGlucose-6-phosphate dehydrogenaseen_US
dc.subjectHexokinaseen_US
dc.subjectKidneyen_US
dc.subjectLactate dehydrogenaseen_US
dc.subjectMalate dehydrogenaseen_US
dc.titleThe Effects of Cisplatin on the Kidney Metabolism: Role of Ginkgo Biloba Extracten_US
dc.title.alternativeSisplatinin Böbrek Metabolizmasi Üzerine Etkileri: Gingko Biloba Ekstraktinin Koruyuculu?uen_US
dc.typeArticleen_US

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