Neurosteroid Levels in Patients with Obsessive-Compulsive Disorder

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dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authoriderbay, lale gönenir/0000-0002-9969-3016
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosiderbay, lale gönenir/AAE-6285-2019
dc.contributor.authorErbay, Lale Gonenir
dc.contributor.authorKartalci, Sukru
dc.date.accessioned2024-08-04T20:41:18Z
dc.date.available2024-08-04T20:41:18Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective Changes in serum neurosteroid levels have been reported in stress-related disorders such as anxiety and depression, but not in patients with obsessive-compulsive disorder (OCD). We thus investigated such changes in patients with OCD. Methods We compared the serum levels of progesterone, pregnanolone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEA-S), cortisol and testosterone in 30 patients with OCD and 30 healthy controls. Results When male and female patients were evaluated together, DHEA and cortisol levels were significantly higher in patients with OCD than the control group. When the genders were evaluated separately, DHEA and cortisol levels were higher in female patients than the female controls. The increase in DHEA levels in female patients is likely an effect of the hypothalamic-pituitary-adrenal (HPA) axis. In contrast, cortisol levels in male patients were higher than the control group, while testosterone levels were lower. The increased cortisol and decreased testosterone levels in male patients likely involves the hypothalamic-pituitary-gonadal (HPG) axis. Conclusion These findings suggest that neurosteroid levels in patients with OCD should be investigated together with the HPA and HPG axes in future studies.en_US
dc.identifier.doi10.4306/pi.2015.12.4.538
dc.identifier.endpage544en_US
dc.identifier.issn1738-3684
dc.identifier.issn1976-3026
dc.identifier.issue4en_US
dc.identifier.pmid26508966en_US
dc.identifier.scopus2-s2.0-84946551751en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage538en_US
dc.identifier.urihttps://doi.org/10.4306/pi.2015.12.4.538
dc.identifier.urihttps://hdl.handle.net/11616/97043
dc.identifier.volume12en_US
dc.identifier.wosWOS:000363988700016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Neuropsychiatric Assocen_US
dc.relation.ispartofPsychiatry Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObsessive-compulsive disorderen_US
dc.subjectNeurosteroiden_US
dc.subjectGenderen_US
dc.titleNeurosteroid Levels in Patients with Obsessive-Compulsive Disorderen_US
dc.typeArticleen_US

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