Extracellular Histones H3 as a Prognostic Blood Marker for Delayed Liver Function Recovery After Donor Hepatectomy

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dc.authoridBayramov, Nuru/0000-0001-6958-5412
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridince, volkan/0000-0002-0714-490X
dc.authorwosidBayramov, Nuru/GOK-0042-2022
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidBayramov, Nuru/KFT-2205-2024
dc.authorwosidince, volkan/M-7325-2017
dc.contributor.authorNovruzov, Namig
dc.contributor.authorErsan, Veysel
dc.contributor.authorBayramov, Nuru
dc.contributor.authorOtlu, Baris
dc.contributor.authorAliyev, Eldar
dc.contributor.authorInce, Volkan
dc.contributor.authorIsik, Burak
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Early prediction of liver dysfunction after liver resection remains a challenge. We hypothesized that extracellular histone concentrations are a promising new biomarker for the detection of liver injury after donor hepatectomy. Methods. This prospective study considered 93 living donors who underwent hepatectomy. Blood samples of donors were collected on postoperative day 1, and histone levels in the plasma samples of the patients were measured with total histone H3 sandwich ELISA kits. Among 86 right lobe donors, 23 (26.7%) were deemed to have a delayed liver function recovery according to the International Study Group of Liver Surgery's definition of posthepatectomy liver failure, whereas 63 (73.3%) were considered to have an adequate liver function recovery. Results. The area under the receiver operating characteristic (ROC) curve for circulating histo-nes in predicting persistent liver dysfunction was 0.618 +/- 0.06 (95% confidence interval [CI], 0.501-0.735; P = .091). The cutoff point value obtained from the analysis of ROC curves was 0.895, with a sensitivity of 95.7% and a specificity of 32.9%, respectively, for examining a delayed liver function recovery (P = .015). The Fisher analysis significantly verified these results empirical influence function % 7.90 (95% CI, 3.91-11.90; P = .006). The univariate analysis determined that postoperative histones were identified as an independent risk factor of delayed liver function recovery (odds ratio, 10.8; 95% CI, 1.4-84.9; P = .024). Conclusions. The circulating histone negatively correlates with liver dysfunctions after donor hepatectomy and had the best value in predicting liver dysfunction within 24 hours after liver resection.en_US
dc.identifier.doi10.1016/j.transproceed.2021.07.023
dc.identifier.endpage2311en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue7en_US
dc.identifier.pmid34452737en_US
dc.identifier.scopus2-s2.0-85113567326en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2305en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2021.07.023
dc.identifier.urihttps://hdl.handle.net/11616/100162
dc.identifier.volume53en_US
dc.identifier.wosWOS:000701266100031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCirculating Histonesen_US
dc.subjectMediatorsen_US
dc.subjectInjuryen_US
dc.subjectDeathen_US
dc.titleExtracellular Histones H3 as a Prognostic Blood Marker for Delayed Liver Function Recovery After Donor Hepatectomyen_US
dc.typeArticleen_US

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