Development of 1,2,3-Triazolopyridazinone Derivatives as Potential Caspase 3 and Apoptosis Inducers: Design, Synthesis and Anticancer Activity Studies

Basit Öğe Kaydı
dc.contributor.authorErdemir, Guler Yagiz
dc.contributor.authorKurucay, Ali
dc.contributor.authorAtes, Burhan
dc.contributor.authorAltundas, Aliye
dc.date.accessioned2026-04-04T13:37:38Z
dc.date.available2026-04-04T13:37:38Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractHerein, the synthesis, anticancer activity and apoptotic pathways of 1,2,3-triazolopyridazinones compounds, which are similar to DNA bases not previously found in the literature have been investigated. To achieve this goal, it is designed the hybrid molecules combining triazole and pyridazinone/pyridazithione structures, bearing a lipophilic group (benzyl/phenyl) at the one position and benzene with electron withdrawing or donating groups at five positions, with high pharmacophoric properties on the same scaffold structure. The representative compounds in this series 5a, 5c, 6a and 8c exhibited higher anticancer activity than other compounds and cisplatin control against breast (MCF-7) and lung (A549) cell lines. These compounds were less toxic when tested against the noncancerous L929 cell line. In addition, the apoptotic effect mechanisms of these compounds were confirmed by AO/EB staining and caspase 3 activity results. These findings indicate that some derivatives of these compounds could be effective therapeutic agents for the treatment of cancer disease with an apoptosis-promoting.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu
dc.description.sponsorshipFinancial support was provided by the Turkiye Bilimsel ve Teknolojik Arastirma Kurumu
dc.identifier.doi10.1002/jbt.70216
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue3
dc.identifier.orcid0000-0003-4616-4513
dc.identifier.pmid40079268
dc.identifier.scopus2-s2.0-105000286396
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.70216
dc.identifier.urihttps://hdl.handle.net/11616/109965
dc.identifier.volume39
dc.identifier.wosWOS:001443288000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subject1,2,3-triazole
dc.subjectanticancer
dc.subjectapoptosis
dc.subjectcaspase 3 activity
dc.subjectpyridazinone
dc.subjecttriazolopyridazinone
dc.titleDevelopment of 1,2,3-Triazolopyridazinone Derivatives as Potential Caspase 3 and Apoptosis Inducers: Design, Synthesis and Anticancer Activity Studies
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu