Investigation of a nosocomial outbreak by alginate-producing pan-antibiotic-resistant Pseudomonas aeruginosa

Basit Öğe Kaydı
dc.authoridOzden, Mehmet/0000-0002-1202-0864
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidYAKUPOGULLARI, YUSUF/F-3966-2011
dc.authorwosidOzden, Mehmet/ABI-5449-2020
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.contributor.authorYakupogullari, Yusuf
dc.contributor.authorOtlu, Baris
dc.contributor.authorDogukan, Muruvvet
dc.contributor.authorGursoy, Canan
dc.contributor.authorKorkmaz, Ebru
dc.contributor.authorKizirgil, Ahmet
dc.contributor.authorOzden, Mehmet
dc.date.accessioned2024-08-04T20:31:05Z
dc.date.available2024-08-04T20:31:05Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The nosocomial spread of pan-antibiotic-resistant nonfermentative bacteria is an increasing concern. This study investigated the microbiologic and epidemiologic characteristics of a hospital outbreak due to alginate-producing, pan-antibiotic-resistant Pseudomonas aeruginosa (PAR-Pa). Methods: All patients with infection with a P aeruginosa strain that was resistant to all Clinic Laboratory Standards Institute-suggested antimicrobial agents between November 2004 and May 2005 were included in the study. Alginate production detection and pulsed-field gel electrophoresis (PFGE) typing were done for the patient and environmental surveillance isolates. A matched case-control study was performed to identify risk factors and evaluate outcomes. Results: PFGE analysis of a total of 35 PAR-Pa isolates (28 patient and 7 environmental surveillance isolates) identified a single epidemic clone as responsible for the outbreak. All epidemic isolates were alginate-producing and susceptible only to colistin. The Student t-test demonstrated that a longer stay in the intensive care unit (ICU) (6.64 days vs 1.83 days; P < .05) significantly increased the risk of PAR-Pa infection. Systemic PAR-Pa infection resulted in higher mortality (85.7% vs 27.8%; P < .05). Multivariate analysis determined that therapeutic failure (odds ratio 5 24.7; 95% confidence interval 5 4.144 to 147.221; P < .05) was the independent risk factor related to this high mortality. Localized PAR-Pa infections were associated with longer hospital stays (46.2% vs 14.4%; P < .05) and higher rates of surgery (85.7% vs 15.4%; P < .05) and amputation (42.8% vs 0%; P < .05). The recovery of the pathogen from staff hands and frequently handled surfaces suggests possible handborne transmission. Improved hygienic standards and application of strict contact precautions, including isolation, reduced the spread of the pathogen. Conclusion: This study illustrates the ability of pan-antibiotic-resistant P aeruginosa to cause an outbreak with significant mortality and stresses the need for precautions to prevent the spread of such highly resistant strains.en_US
dc.identifier.doi10.1016/j.ajic.2008.07.006
dc.identifier.endpageE18en_US
dc.identifier.issn0196-6553
dc.identifier.issn1527-3296
dc.identifier.issue10en_US
dc.identifier.pmid19084158en_US
dc.identifier.scopus2-s2.0-57349086216en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE13en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajic.2008.07.006
dc.identifier.urihttps://hdl.handle.net/11616/94711
dc.identifier.volume36en_US
dc.identifier.wosWOS:000477638400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofAmerican Journal of Infection Controlen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfectionsen_US
dc.subjectColistinen_US
dc.titleInvestigation of a nosocomial outbreak by alginate-producing pan-antibiotic-resistant Pseudomonas aeruginosaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu