Hepatoprotective properties for Salvia cryptantha extract on carbon tetrachloride-induced liver injury

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dc.authoridUğur, Kader/0000-0003-4028-2041
dc.authoridPehlivan, Mustafa/0000-0002-8277-6085
dc.authoridkuloğlu, tuncay/0000-0001-9874-3838
dc.authoridparlar, ali/0000-0002-4656-3402
dc.authoridAydın, Hasan/0000-0002-1955-6178
dc.authoridTURK, AHMET/0000-0003-0903-3522
dc.authorwosidUğur, Kader/W-7053-2018
dc.authorwosiddoğukan, mevlüt/HJY-5235-2023
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidPehlivan, Mustafa/AAG-6494-2020
dc.authorwosidkuloğlu, tuncay/W-2310-2018
dc.authorwosidparlar, ali/U-6786-2019
dc.authorwosidAydın, Hasan/AGY-1655-2022
dc.contributor.authorYalcin, Alper
dc.contributor.authorYumrutas, Onder
dc.contributor.authorKuloglu, Tuncay
dc.contributor.authorElibol, Ebru
dc.contributor.authorParlar, Ali
dc.contributor.authorYilmaz, Ismet
dc.contributor.authorPehlivan, Mustafa
dc.date.accessioned2024-08-04T20:44:14Z
dc.date.available2024-08-04T20:44:14Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study was designed to determine the possible hepatoprotective effects of Salvia cryptantha (black weed) plant extract against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Animals were grouped as follows: control group (Group I), CCl4 group (Group II), olive oil group (Group III), CCl4 + S. cryphantha 200 mg/kg group (Group IV), and CCl4 + S. cryptantha 400 mg/kg group (Group V). Rats were injected intraperitoneally with CCl4 diluted in olive oil (50% v/v) at a dose of 1ml/kg body weight. Bax and Caspase3 were determined by immunohistochemical staining, while apoptotic index was evaluated using TUNEL assay. Total mRNA was isolated from liver tissues, and the levels of BCL2, Caspase3, SOD, CAT, and glutathione peroxidase (GPx) were determined by using PCR, while MDA level were determined using a colorimetric assay. The antioxidant and anti-apoptotic gene transcripts were decreased in all of the control and treatment groups, while Caspase3 levels were not statistically different. The S. cryptantha plant extract treatment was also found to improve SOD, GPx, and catalase levels, while reducing the serum levels of MDA. The extract of S. cryptantha supplementation had a protective effect against CCl4-induced liver damage. S. cryptantha extract as a supplement may be useful as a hepato-protective agent to combat the toxic effects caused by CCl4 and other chemicals.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Adiyaman University [TIPFBAP/2014-0008]; Adiyaman Universityen_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Adiyaman University (TIPFBAP/2014-0008). The authors would like to thank Adiyaman University for kindly supporting this research. This study was presented as a poster at The 2nd International Gazi Pharma Symposium Series (1113 October, 2017), Ankara, Turkey.en_US
dc.identifier.doi10.14715/cmb/2017.63.12.13
dc.identifier.endpage62en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue12en_US
dc.identifier.pmid29307343en_US
dc.identifier.scopus2-s2.0-85040006693en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage56en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.12.13
dc.identifier.urihttps://hdl.handle.net/11616/98104
dc.identifier.volume63en_US
dc.identifier.wosWOS:000419272800013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectTUNELen_US
dc.subjectCaspase3en_US
dc.subjectBCL2en_US
dc.subjectLiver injuryen_US
dc.subjectSalvia cryptanthaen_US
dc.titleHepatoprotective properties for Salvia cryptantha extract on carbon tetrachloride-induced liver injuryen_US
dc.typeArticleen_US

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