Effects of laser irradiation at different wavelengths (660, 810, 980, and 1064 nm) on transient receptor potential melastatin channels in an animal model of wound healing

Basit Öğe Kaydı
dc.authoridTopcuoglu, Tolga/0000-0001-5600-245X
dc.authoridYolcu, Ümit/0000-0001-7312-2867
dc.authoridBayraktar, Recep/0000-0002-8227-2055
dc.authoridARAS, Mutan/0000-0002-8907-7340
dc.authorwosidUsumez, Aslihan/Z-4568-2019
dc.authorwosidTopcuoglu, Tolga/HKW-6572-2023
dc.authorwosidYolcu, Ümit/ABH-6916-2020
dc.authorwosidCengiz, Beyhan/AAC-8976-2022
dc.contributor.authorIsman, Eren
dc.contributor.authorAras, Mutan Hamdi
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorBayraktar, Recep
dc.contributor.authorYolcu, Umit
dc.contributor.authorTopcuoglu, Tolga
dc.contributor.authorUsumez, Aslihan
dc.date.accessioned2024-08-04T20:40:19Z
dc.date.available2024-08-04T20:40:19Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the present study was to compare the effectiveness of four different laser wavelengths used for low-level laser therapy(LLLT) on healing of mucositis in an animal model of wound healing, by investigating expression of transient receptor potential melastatin(TRPM) ion channels. Forty-five rats were intraperitoneally injected with 100 mg/kg 5-fluorouracil on day 1 and 65 mg/kg on day 3. Superficial scratching on left cheek pouch mucosa was performed on days 3 and 5. After ulcerative mucositis was clinically detected, LLLT was started (660 nm, HELBO; 810 nm, Fotona-XD; 980 nm, ARC-Fox; and 1064 nm, Fidelis-Plus3) at 8 J/cm(2)/day from days 1 to 4. Oval excisional biopsy was performed at the wound site, and expression of TRPM2 to TRPM8 was evaluated. Student's t test was used for evaluation of significance of TRPM gene expression according to 0 value (alpha = 0.05). In 980-nm group, TRPM4, TRPM6, and TRPM7 were significantly higher than in the control group (p < 0.005). In 660, 810, and 1064 nm groups, only TRPM6 was significantly higher than in control group (p < 0.005). There were no significant differences between control and sham groups (p > 0.05). These findings suggest that expression of TRPM6 gene was significantly affected by irradiation with lasers at different wavelengths, whereas the TRPM4 and TRPM7 genes were only expressed in the 980-nm diode laser group. TRPM6 gene was highly expressed during LLLT, which may lead to accelerated wound healing and tissue repair. In contrast, there was some evidence that the 980-nm diode laser caused increased expression of TRPM4, TRPM6, and TRPM7 which are responsible for stimulation of Ca2+ and Mg2+ metabolism, as well as apoptotic pathways of controlled cell death.en_US
dc.identifier.doi10.1007/s10103-015-1750-5
dc.identifier.endpage1495en_US
dc.identifier.issn0268-8921
dc.identifier.issn1435-604X
dc.identifier.issue5en_US
dc.identifier.pmid25863514en_US
dc.identifier.scopus2-s2.0-84931571082en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1489en_US
dc.identifier.urihttps://doi.org/10.1007/s10103-015-1750-5
dc.identifier.urihttps://hdl.handle.net/11616/96844
dc.identifier.volume30en_US
dc.identifier.wosWOS:000356531400010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofLasers in Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTRPM geneen_US
dc.subjectWound healingen_US
dc.subjectLow-level laser therapyen_US
dc.subjectApoptosisen_US
dc.subjectCa2+ Mg2+ metabolismen_US
dc.subjectLLLTen_US
dc.titleEffects of laser irradiation at different wavelengths (660, 810, 980, and 1064 nm) on transient receptor potential melastatin channels in an animal model of wound healingen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu