Update on treatment options for spinal brucellosis

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dc.authoridInal, Ayse Seza/0000-0002-1182-7164
dc.authoridOzturk-Engin, Derya/0000-0002-2566-7317
dc.authoridKarabay, Oguz/0000-0003-1514-1685
dc.authoridAydın, Mehtap/0000-0003-4044-9366
dc.authoridAk, Öznur/0000-0003-3790-3070
dc.authoridErdem, Hakan/0000-0002-6265-5227
dc.authoridSaltoglu, Nese/0000-0003-4239-9585
dc.authorwosidSalto?lu, Neşe/AAV-2262-2021
dc.authorwosidInal, Ayse Seza/B-7367-2016
dc.authorwosidDeveci, ozcan/A-2031-2017
dc.authorwosidInan, Asuman/IXW-7212-2023
dc.authorwosidsener, alper/F-6427-2011
dc.authorwosidSALTOGLU, NESE/AAJ-5552-2021
dc.authorwosidOzturk-Engin, Derya/AFG-5927-2022
dc.contributor.authorUlu-Kilic, A.
dc.contributor.authorKarakas, A.
dc.contributor.authorErdem, H.
dc.contributor.authorTurker, T.
dc.contributor.authorInal, A. S.
dc.contributor.authorAk, O.
dc.contributor.authorTuran, H.
dc.date.accessioned2024-08-04T20:38:01Z
dc.date.available2024-08-04T20:38:01Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe evaluated the efficacy and tolerability of antibiotic regimens and optimal duration of therapy in complicated and uncomplicated forms of spinal brucellosis. This is a multicentre, retrospective and comparative study involving a total of 293 patients with spinal brucellosis from 19 health institutions. Comparison of complicated and uncomplicated spinal brucellosis was statistically analysed. Complicated spinal brucellosis was diagnosed in 78 (26.6%) of our patients. Clinical presentation was found to be significantly more acute, with fever and weight loss, in patients in the complicated group. They had significantly higher leukocyte and platelet counts, erythrocyte sedimentation rates and C-reactive protein levels, and lower haemoglobulin levels. The involvement of the thoracic spine was significantly more frequent in complicated cases. Spondylodiscitis was complicated, with paravertebral abscess in 38 (13.0%), prevertebral abscess in 13 (4.4%), epidural abscess in 30 (10.2%), psoas abscess in 10 (3.4%) and radiculitis in 8 (2.7%) patients. The five major combination regimens were: doxycycline 200mg/day, rifampicin 600mg/day and streptomycin 1g/day; doxycycline 200mg/day, rifampicin 600mg/day and gentamicin 5mg/kg; doxycycline 200mg/day and rifampicin 600mg/day; doxycycline 200mg/day and streptomycin 1g/day; and doxycycline 200mg/day, rifampicin 600mg/day and ciprofloxacin 1g/day. There were no significant therapeutic differences between these antibiotic groups; the results were similar regarding the complicated and uncomplicated groups. Patients were mostly treated with doxycycline and rifampicin with or without an aminoglycoside. In the former subgroup, complicated cases received antibiotics for a longer duration than uncomplicated cases. Early recognition of complicated cases is critical in preventing devastating complications. Antimicrobial treatment should be prolonged in complicated spinal brucellosis in particular.en_US
dc.identifier.doi10.1111/1469-0691.12351
dc.identifier.endpageO82en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue2en_US
dc.identifier.pmid24118178en_US
dc.identifier.scopus2-s2.0-84892478603en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageO75en_US
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12351
dc.identifier.urihttps://hdl.handle.net/11616/96320
dc.identifier.volume20en_US
dc.identifier.wosWOS:000329585200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofClinical Microbiology and Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBrucellosisen_US
dc.subjectspondylitisen_US
dc.subjectspondylodiscitisen_US
dc.subjecttreatmenten_US
dc.titleUpdate on treatment options for spinal brucellosisen_US
dc.typeArticleen_US

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