Bipolar affektif bozukluklu hastalarda lityum ve olanzapin tedavisinin etkileri: Beyin MRSs bulguları
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Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Anadolu Psikiyatri Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz: Amaç: Bu çalışmada, remisyon dönemindeki bipolar affektif bozukluklu hastalarda lityum ve olanzapin tedavisi ile beyin manyetik rezonans spektroskopi (MR spektroskopi) bulgularındaki değişiklikler ve bunun nöroprotektivite ile ilişkisi araştırıldı. Yöntem: Psikiyatri polikliniğinde izlenen, 3 yıl boyunca manik ve depresif bir atak geçirmemiş ve son 6 aydır sadece lityum tedavisi almakta olan 10 bipolar affektif bozukluk hastası çalışmaya alındı. Hastalar lityum kullandıkları dönemde, lityumun kesilmesini takiben 14. günde ve olanzapin başlandıktan sonraki 4. haftanın sonunda olmak üzere 3 kez değerlendirildi. Her bir değerlendirme klinik psikiyatrik görüşme, Hamilton depresyon derecelendirme Ölçeği (HDÛÖ) ve Bech-Rafaelson Mani Ölçeği (BRMÖ) uygulaması ve MR spektroskopi çekimini kapsadı. MR spektroskopide, sağ prefrontal korteks ve sol hipokampüs bölgelerinde kantitatif olarak N-asetil aspartat (NAA), kolin (Cho) pikleri ölçüldü ve bunların kreatine (Cr) pikine oranlarına bakıldı. Her 3 çekimdeki değerler birbiriyle karşılaştırıldı. Bulgular: Çalışmaya 5 kadın ve 5 erkek hasta katıldı. Ortalama yaşları 33.10+9.17yıl idi. Lityum alırken, ilaçsız dönemde ve.olanzapin alırken çekilen MR spektroskopilerinde NAA/Cr ve Cho/Cr oranları arasında istatistiksel açıdan anlamlı farklılık saptanmadı. Sonuç: Remisyonda bipolar affektif bozukluklu hastalarda lityum ve olanzapin tedavisiyle beyin NAA ve Cho düzeylerinin değişmediğini düşündürmektedir.
Abstract: Objective: In this study we searched the caused by lithium and olanzapine treatment in brain magnetic resonance spetroscopy (MR spectroscopy) and its reladuring remission. Methods: Ten patients with bipolar affective disorders who were followed-up in psychiatry outpatient clinic between February and June 2003, had no manic or depressive attacs for the last 3 years and had lithium as the only therapy for the last 6 months were included in this study. They were evaluated during and 14 days after cessation of lithium treatment and at the end of 4th week on olazapine treatment. Clinical interview, Hamilton Depression Rating Scale (HAM-b) psychometric evaluation test, Brief Psychiatric Rating Scale (BPRS) and magnetic resonance spectroscopy (MR spectroscopy) were assesed on each evaluation. According to the results of interview and psychometric evaluation, patients who were diagnosed as manic or depressive disorder were ruled out of the study. Cases underwent single voxel MR spect with PRESS sequence. The peak of N-acetyl aspartate (NAA), Choline (Cho) and their ratio to Creatinine (Cr) peak were evaluated quantitavely right prefrontal cortex and left hippocampus areas on MR spectroscopy. Results of three MR spects were compared. Results: Five women and 5 men comleted to the study, mean age of the patients were 33.10±9.17. No significant difference was determined between NAA/Cr and Cho/Cr values of MR spects, in each three phases as on lithium treatment, in unmedicated period and in olanzapine treatment. Conclusion: We did not find any significant effect of these drugs on brain NAA and Cho levels in the remission phases of bipolar affective disorder. tionship with neuroprotectivity in patients with bipolar affective disorder
Abstract: Objective: In this study we searched the caused by lithium and olanzapine treatment in brain magnetic resonance spetroscopy (MR spectroscopy) and its reladuring remission. Methods: Ten patients with bipolar affective disorders who were followed-up in psychiatry outpatient clinic between February and June 2003, had no manic or depressive attacs for the last 3 years and had lithium as the only therapy for the last 6 months were included in this study. They were evaluated during and 14 days after cessation of lithium treatment and at the end of 4th week on olazapine treatment. Clinical interview, Hamilton Depression Rating Scale (HAM-b) psychometric evaluation test, Brief Psychiatric Rating Scale (BPRS) and magnetic resonance spectroscopy (MR spectroscopy) were assesed on each evaluation. According to the results of interview and psychometric evaluation, patients who were diagnosed as manic or depressive disorder were ruled out of the study. Cases underwent single voxel MR spect with PRESS sequence. The peak of N-acetyl aspartate (NAA), Choline (Cho) and their ratio to Creatinine (Cr) peak were evaluated quantitavely right prefrontal cortex and left hippocampus areas on MR spectroscopy. Results of three MR spects were compared. Results: Five women and 5 men comleted to the study, mean age of the patients were 33.10±9.17. No significant difference was determined between NAA/Cr and Cho/Cr values of MR spects, in each three phases as on lithium treatment, in unmedicated period and in olanzapine treatment. Conclusion: We did not find any significant effect of these drugs on brain NAA and Cho levels in the remission phases of bipolar affective disorder. tionship with neuroprotectivity in patients with bipolar affective disorder
Açıklama
Anahtar Kelimeler
Kaynak
Anadolu Psikiyatri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
4
Künye
CUMURCU E. B,KARLIDAĞ R,SARAÇ K,ÜNAL S,ÖZCAN C (2004). Bipolar affektif bozukluklu hastalarda lityum ve olanzapin tedavisinin etkileri: Beyin MRSs bulguları. Anadolu Psikiyatri Dergisi, 5(4), 197 - 205.
