DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridUnlu, Mehmet Cihat/0000-0001-5507-3993
dc.authoridCelik, Sudenaz/0000-0002-6964-0191
dc.authorwosidersahin, aynur/AAH-6268-2019
dc.authorwosidCaliskan, Eray/HTR-8541-2023
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidUnlu, Mehmet Cihat/Q-5146-2018
dc.contributor.authorCelik, Onder
dc.contributor.authorAcet, Mustafa
dc.contributor.authorImren, Aytac
dc.contributor.authorCelik, Nilufer
dc.contributor.authorErsahin, Aynur
dc.contributor.authorAktun, Lebriz Hale
dc.contributor.authorOtlu, Baris
dc.date.accessioned2024-08-04T20:44:15Z
dc.date.available2024-08-04T20:44:15Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The study was planned to investigate whether DHEA supplementation had an impact on endometrial receptivity in women who were poor responders (POR). Material and Methods: Twenty-eight POR women who were undergoing hysteroscopy and five fertile control subjects were included. The POR women were equally subdivided into two separate groups as patients who were currently using DHEA and those who were not. Endometrial samples of the subjects were obtained during hysteroscopy at the late follicular phase. Expression levels of endometrial HOXA-10, HOXA-11, and LIF mRNA were measured with the using real-time polymerase chain reaction. Spontaneous clinical pregnancy rates were also noted. Results: Compared with POR women who were not given DHEA, upregulated endometrial HOXA-10 (7.33-fold) and HOXA-11 (2.39-fold) mRNA expression were detected in POR women on DHEA. The increase in HOXA-10 mRNA was significant (p<0.03). The fold increase in HOXA-11 mRNA was found as 2.39, which indicated a positive upregulation. However, this fold increment was insignificant (p<0.45). An insignificant increase in spontaneous clinical pregnancy rates in POR women on DHEA (53.3%) was observed compared with POR women who were not given DHEA (43.8%). Conclusion: Oral DHEA supplementation in POR upregulates endometrial HOXA-10 mRNA expression, which is known to positively modulate endometrial receptivity.en_US
dc.description.sponsorshipTurkish German Gynecologic Research and Education Foundation for HOXA and LIF genes kitsen_US
dc.description.sponsorshipThe authors declared that this study received financial support from Turkish German Gynecologic Research and Education Foundation for HOXA and LIF genes kits.en_US
dc.identifier.doi10.4274/jtgga.2017.0054
dc.identifier.endpage166en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4en_US
dc.identifier.pmid29278227en_US
dc.identifier.scopus2-s2.0-85040678013en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org/10.4274/jtgga.2017.0054
dc.identifier.urihttps://hdl.handle.net/11616/98118
dc.identifier.volume18en_US
dc.identifier.wosWOS:000423956200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriumen_US
dc.subjectDHEAen_US
dc.subjecthomeobox genesen_US
dc.subjectpoor responderen_US
dc.titleDHEA supplementation improves endometrial HOXA-10 mRNA expression in poor respondersen_US
dc.typeArticleen_US

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