Is helical tomotherapy-based intensity-modulated radiotherapy feasible and effective in bilateral synchronous breast cancer? A two-center experience

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dc.authoridkaya pepele, eda/0000-0002-9193-0961
dc.authoridtemelli, oztun/0000-0003-3471-1284
dc.authorwosidEkici, Kemal/AFJ-9488-2022
dc.authorwosidEkici, Kemal/AAF-6505-2022
dc.authorwosidtemelli, Oztun/ABE-6986-2020
dc.authorwosidkaya pepele, eda/HGE-0700-2022
dc.contributor.authorEkici, Kemal
dc.contributor.authorGokce, Tumay
dc.contributor.authorKaradogan, Ilker
dc.contributor.authorEraslan, Aysun Fatma
dc.contributor.authorAkcay, Cimen
dc.contributor.authorTemelli, Oztun
dc.contributor.authorPepele, Eda Kaya
dc.date.accessioned2024-08-04T20:41:46Z
dc.date.available2024-08-04T20:41:46Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: This study describes the early clinical results and dosimetric parameters of intensity-modulated radiation therapy (IMRT) using a tomotherapy device in patients with primary bilateral synchronous breast cancer (PSBBC). Methods: Fourteen patients with bilateral breast cancer were treated with tomotherapy between January 2011 and October 2014. The treatment planning objectives were to cover 95% of the planning target volume using a 95% isodose, with a minimum dose of 90% and a maximum dose of 107%. The organs at risk (OAR), such as the lungs, heart, esophagus and spinal cord, were contoured. Acute toxicity was recorded during and after radiation therapy. Results: The advantages included better treatment conformity with lower dosages to minimize the risk to susceptible organs, such as the lungs, heart and spinal cord. There was improved coverage of the planning target volume, including the regional nodes, without any field junction problems. The median homogeneity index was 0.13 and the median conformity index 1.32. The median V20, V15, V10 and V5 for the total lungs were 18.5, 23.3, 24.2 and 60%, respectively. Skin acute toxicity was grade 1 in 72% and grade 2 in 14% of the patients. Esophageal acute toxicity was grade 1 in 43% of the patients. Conclusion: Tomotherapy delivers treatment that is well-tolerated, with high homogeneity and coverage indexes and the capability to reduce the irradiation dose received by the lungs and heart in PSBBC patients. This technique is therefore feasible and safe for the treatment of bilateral breast cancer.en_US
dc.identifier.endpage52en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue1en_US
dc.identifier.pmid27061530en_US
dc.identifier.scopus2-s2.0-84969142118en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage46en_US
dc.identifier.urihttps://hdl.handle.net/11616/97329
dc.identifier.volume21en_US
dc.identifier.wosWOS:000372859700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbilateral breast canceren_US
dc.subjectintensity modulated radiation therapyen_US
dc.subjectside-effectsen_US
dc.subjecttomotherapyen_US
dc.titleIs helical tomotherapy-based intensity-modulated radiotherapy feasible and effective in bilateral synchronous breast cancer? A two-center experienceen_US
dc.typeArticleen_US

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