The Effects of Aminoguanidine, Methylprednisolone, and Melatonin on Nerve Recovery in Peripheral Facial Nerve Neurorrhaphy

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dc.authoridAKDUMAN, DAVUT/0000-0002-1807-1478
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authorwosidGok, Uzeyir/AAB-8426-2021
dc.authorwosidHaksever, Mehmet/B-3787-2014
dc.authorwosidAKDUMAN, DAVUT/F-9687-2015
dc.authorwosidHaksever, Mehmet/GPG-3456-2022
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.contributor.authorYanilmaz, Muhammed
dc.contributor.authorAkduman, Davut
dc.contributor.authorSagun, Omer Faik
dc.contributor.authorHaksever, Mehmet
dc.contributor.authorYazicilar, Osman
dc.contributor.authorOrhan, Israfil
dc.contributor.authorAkpolat, Nusret
dc.date.accessioned2024-08-04T20:41:26Z
dc.date.available2024-08-04T20:41:26Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: The medications may enhance the recovery after nerve paralysis. We aimed to evaluate the effects of aminoguanidine (AG), melatonin, and methylprednisolone on peripheral facial nerve neurorrhaphy. Methods: The buccal branch of the facial nerve was transected and autografted in 32 New Zealand rabbits. Subjects were divided into 4 groups equally (AG, melatonin, methylprednisolone, and control). After the medical treatment latency and amplitude were measured with nerve conduction study at 3, 6, and 10 weeks. Then, coapted segments of nerve were examined microscopically. The groups were compared with each other. Results: The latent period was shortened, and the amplitudes were increased in the AG group; the latent period was shortened, and the amplitudes did not show significant change in the melatonin group with the time. There were no significant differences between the amplitudes at 3 to 6 and 3 to 10 weeks in the methylprednisolone group, and the latent period was shortened. There was no significant difference between the amplitude values at 3, 6, and 10 weeks in the control group. In the histological examination, AG had the best influence on preventing myelin degeneration and reducing the accumulation of myelin debris. Considering the increase in collagen fibers, the best results were achieved in the melatonin group. The degree of myelin-axonal degeneration was higher in the methylprednisolone group. The degree of collagen fiber increase, axonal degeneration, myelin degeneration, and the accumulation of myelin debris were detected quite high in the control group. Conclusions: Aminoguanidine and melatonin alone achieved an increase in regeneration after peripheral facial nerve neurorrhaphy, but methylprednisolone did not. The best healing was determined in the AG group.en_US
dc.identifier.doi10.1097/SCS.0000000000001503
dc.identifier.endpage672en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue3en_US
dc.identifier.pmid25933145en_US
dc.identifier.scopus2-s2.0-84953342475en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage667en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000001503
dc.identifier.urihttps://hdl.handle.net/11616/97102
dc.identifier.volume26en_US
dc.identifier.wosWOS:000355236700049en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFacial nerveen_US
dc.subjectfacial paralysisen_US
dc.subjectaminoguanidineen_US
dc.subjectmelatoninen_US
dc.subjectmethylprednisoloneen_US
dc.subjectnerve conduction studyen_US
dc.subjectlatent perioden_US
dc.subjectamplitudeen_US
dc.titleThe Effects of Aminoguanidine, Methylprednisolone, and Melatonin on Nerve Recovery in Peripheral Facial Nerve Neurorrhaphyen_US
dc.typeArticleen_US

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