The effects of hormone replacement therapy on echocardiographic basic cardiac functions in postmenopausal women

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dc.authoridMuderrisoglu, Haldun/0000-0002-9635-6313
dc.authorwosidtaskin, omur/C-6864-2016
dc.authorwosidMuderrisoglu, Haldun/AAG-8233-2020
dc.contributor.authorTaskin, O
dc.contributor.authorGökdeniz, R
dc.contributor.authorMuderrisoglu, H
dc.contributor.authorKorkmaz, ME
dc.contributor.authorUryan, I
dc.contributor.authorAtmaca, R
dc.contributor.authorKafkasli, A
dc.date.accessioned2024-08-04T20:11:58Z
dc.date.available2024-08-04T20:11:58Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description51st Annual Meeting of the American-Society-for-Reproductive-Medicine -- OCT 07-13, 1995 -- SEATTLE, WAen_US
dc.description.abstractThis prospective study was designed to investigate the effects of hormone replacement therapy (HRT) on systolic and diastolic functions. Twenty-eight non-smoking, healthy postmenopausal women who had not received any kind of HRT for at least three years within the onset of menopause were included in the study. Ail patients received 0.625 mg conjugated oestrogens and 2.5 mg medroxyprogesterone acetate as daily HRT regimen. Their basic systolic and diastolic functions were investigated echocardiographically using standard positions and windows before and 6 months after initiation of HRT, The means of age, weight and length of postmenopausal period were 49.3 +/- 5.8 years, 63.5 +/- 8.7 kg and 46.3 +/- 7.1 months, respectively, Heart rate and systolic and diastolic pressures were similar during the pre- and post-treatment periods. After 6 months of HRT, the mean left ventricular end-systolic and end-diastolic volumes were decreased significantly (71.3 +/- 16.4 versus 56.3 +/- 22.8 mi, 144.5 +/- 26.1 versus 111.7 +/- 24.0 mi, respectively, P <0.05), Left ventricular ejection fraction was increased (45.1 +/- 6.2% versus 54.8 +/- 4.1%, P < 0.05), Improvement in diastolic function was significant compared with the pretreatment period (E/A 0.90 +/- 0.2 versus 1.10 +/- 0.4, deceleration time 238 +/- 36.8 versus 201 +/- 24.2 ms, respectively, P < 0.05), Based on our preliminary results, we conclude that besides the known favourable effects on women's lives, HRT may also improve cardiac performance and age-related dysfunctions. The present results further suggest that oestrogens exert many direct effects on the cardiovascular system, other than the metabolic changes related to lipoproteins.en_US
dc.description.sponsorshipAmer Soc Reprod Meden_US
dc.identifier.doi10.1093/humrep/13.9.2399
dc.identifier.endpage2401en_US
dc.identifier.issn0268-1161
dc.identifier.issn1460-2350
dc.identifier.issue9en_US
dc.identifier.pmid9806256en_US
dc.identifier.scopus2-s2.0-0031659862en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2399en_US
dc.identifier.urihttps://doi.org/10.1093/humrep/13.9.2399
dc.identifier.urihttps://hdl.handle.net/11616/93103
dc.identifier.volume13en_US
dc.identifier.wosWOS:000077290900017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofHuman Reproductionen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectechocardiographyen_US
dc.subjecthearten_US
dc.subjecthormone replacement therapyen_US
dc.subjectmenopauseen_US
dc.subjectoestrogenen_US
dc.titleThe effects of hormone replacement therapy on echocardiographic basic cardiac functions in postmenopausal womenen_US
dc.typeConference Objecten_US

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