Comparison of polycaprolactone and calcium hydroxylapatite dermal fillers in a rat model

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dc.authoridMantar Yanatma, Irem/0000-0002-4772-5397
dc.contributor.authorYanatma, Irem
dc.contributor.authorSarac, Gulbahar
dc.contributor.authorGul, Mehmet
dc.contributor.authorGul, Semir
dc.contributor.authorKapicioglu, Yelda
dc.date.accessioned2024-08-04T20:49:13Z
dc.date.available2024-08-04T20:49:13Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPolycaprolactone (PCL) and calcium hydroxylapatite (CaHA) are semipermanent dermal fillers that are frequently preferred in the last decade. This study aims to compare the effects of these two fillers in the rat skin. A total of 30 female rats were divided into; control, PCL, and CaHA group. Tissue samples taken at the second and fourth month were stained with hematoxylin-eosin, Masson trichrome, collagen type 1, and 3 immunohistochemical antibodies. Collagen density was quantitatively compared using the Image J computer program. At 2 and 4 months, the density of collagen increased in both filler groups compared to the control group. There was no significant difference between collagen density or type 1 and type 3 collagen H scores in the filler groups. The number of fibroblast nuclei was significantly higher in the PCL group at 4 months compared to the other two groups. Dermis thickness was found to be superior in both filler groups compared to the control group at the fourth month, there was no significant difference between the filler groups. We compared the effect of CaHA and PCL filler on collagenization histologically and immunohistochemically. We found that PCL and CaHA fillers are effective in increasing dermal collagen density, type 1 and type 3 collagen amount, and preventing dermis atrophy and showed that they have no advantage over each other in this respect. We have shown that PCL filler provides more fibroblast increase compared to CaHA filler and the effect of stimulating fibroblast proliferation takes longer.en_US
dc.description.sponsorshipInonu University Scientific Research Projectsen_US
dc.description.sponsorshipInonu University Scientific Research Projectsen_US
dc.identifier.doi10.1111/dth.14716
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue1en_US
dc.identifier.pmid33368862en_US
dc.identifier.scopus2-s2.0-85099042691en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.14716
dc.identifier.urihttps://hdl.handle.net/11616/99706
dc.identifier.volume34en_US
dc.identifier.wosWOS:000604429800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcalcium hydroxylapatiteen_US
dc.subjectdermal fillersen_US
dc.subjectpolycaprolactoneen_US
dc.titleComparison of polycaprolactone and calcium hydroxylapatite dermal fillers in a rat modelen_US
dc.typeArticleen_US

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