Glial cell line-derived neurotrophic factor and synaptophysin expression in pelviureteral junction obstruction

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridAkin, Melih/0000-0001-9269-8001
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidtürkmen, emine/GXH-9319-2022
dc.authorwosidCelbiş, Osman/ABE-2803-2021
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.contributor.authorDemirbilek, S
dc.contributor.authorEdali, MN
dc.contributor.authorGürünlüoglu, K
dc.contributor.authorTürkmen, E
dc.contributor.authorTas, E
dc.contributor.authorKaraman, A
dc.contributor.authorAkin, M
dc.date.accessioned2024-08-04T20:15:14Z
dc.date.available2024-08-04T20:15:14Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. To examine the expression of neuronal markers in congenital pelviureteral junction (PUJ) obstruction as a causative factor. The findings from some investigations have suggested that defective neuronal innervation may play an important role in the pathogenesis of PUJ obstruction. Methods. Using specific antibodies, we studied the neuronal markers of specimens from 12 cases of PUJ obstruction and 10 normal PUJs by immunohistochemistry using glial cell line-derived neurotrophic factor (GDNF), synaptophysin, S-100, and neurofilament. Results. In the PUJ obstruction specimens, staining with hematoxylin-eosin and Masson's trichrome revealed muscular hypertrophy and an increase in collagen tissue and fibrosis in the lamina propria and tunica muscularis. The most striking finding on immunohistochemistry was the marked nuclear staining of cells with synaptophysin in all layers of the PUJ obstruction specimens that was totally absent in the normal PUJ specimens. In addition, significantly less intense staining for GDNF was found in the PUJ obstruction specimens compared with the normal PUJ specimens. The underexpression of GDNF in PUJ obstruction specimens was localized in the muscular layer especially. Immunohistochemical staining for S-100 and neurofilament showed no differences in the expression level of these neuronal markers in normal and PUJ obstruction specimens. Conclusions. Because GDNF is a survival factor for central and peripheral neurons, defective expression of GDNF could play an important role in the defective neuronal innervation of PUJ obstruction. Intense nuclear expression of synaptophysin in all layers of obstructed PUJ specimens suggested that obstructed PUJs have a serious structural abnormality.en_US
dc.identifier.doi10.1016/j.urology.2005.08.056
dc.identifier.endpage405en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue2en_US
dc.identifier.pmid16461096en_US
dc.identifier.scopus2-s2.0-31944438469en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage400en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2005.08.056
dc.identifier.urihttps://hdl.handle.net/11616/94256
dc.identifier.volume67en_US
dc.identifier.wosWOS:000236178500037en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUreteropelvic Junctionen_US
dc.subjectRenal Pelvisen_US
dc.subjectHydronephrosisen_US
dc.subjectInnervationen_US
dc.subjectProteinen_US
dc.titleGlial cell line-derived neurotrophic factor and synaptophysin expression in pelviureteral junction obstructionen_US
dc.typeArticleen_US

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