Effects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental study

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dc.authoridGul, Mehmet/0000-0002-5721-8778
dc.authoridTekin, Samet/0000-0001-8883-8307
dc.authoridToy, Vesile Elif/0000-0001-5183-6295
dc.authoridKIRTAY, Mustafa/0000-0003-2568-7470
dc.authoridYILMAZ BOZOGLAN, Merve/0000-0001-6058-4579
dc.authoridBozoglan, Alihan/0000-0003-3420-5816
dc.authoridBulmus, Ozgur/0000-0001-7736-402X
dc.authorwosidGul, Mehmet/AAU-1991-2020
dc.authorwosidTekin, Samet/GNH-3187-2022
dc.authorwosidDundar, Serkan/V-8159-2018
dc.authorwosidToy, Vesile Elif/ABH-9210-2020
dc.authorwosidKIRTAY, Mustafa/ABA-7066-2021
dc.contributor.authorDundar, Serkan
dc.contributor.authorBozoglan, Alihan
dc.contributor.authorBulmus, Ozgur
dc.contributor.authorTekin, Samet
dc.contributor.authorYildirim, Tuba Talo
dc.contributor.authorKirtay, Mustafa
dc.contributor.authorToy, Vesile Elif
dc.date.accessioned2024-08-04T20:47:07Z
dc.date.available2024-08-04T20:47:07Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.en_US
dc.description.sponsorshipFirat University Scientific Research Project Foundation Department, Elazig, Turkey [DHF.16.05]en_US
dc.description.sponsorshipThis study was supported by Firat University Scientific Research Project Foundation Department, Elazig, Turkey with the project number DHF.16.05. The authors wish to thanks Bioinfinity Dental Implant System, Avrupa Dental Implant Corporation, Istanbul, Turkey for manufacturing and providing the titanium implants.en_US
dc.identifier.doi10.1590/1807-3107bor-2020.vol34.0008
dc.identifier.issn1807-3107
dc.identifier.pmid32049109en_US
dc.identifier.scopus2-s2.0-85079337795en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1590/1807-3107bor-2020.vol34.0008
dc.identifier.urihttps://hdl.handle.net/11616/99179
dc.identifier.volume34en_US
dc.identifier.wosWOS:000651295100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSociedade Brasileira De Pesquisa Odontologicaen_US
dc.relation.ispartofBrazilian Oral Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydrocortisoneen_US
dc.subjectDieten_US
dc.subjectHigh-Faten_US
dc.subjectOsseointegrationen_US
dc.subjectBone-Implant Interfaceen_US
dc.titleEffects of restraint stress and high-fat diet on osseointegration of titanium implants: an experimental studyen_US
dc.typeArticleen_US

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