Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial

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dc.authoridErol, Ozge/0000-0001-9007-7877
dc.authoridBas, Murat/0000-0002-0494-301X
dc.contributor.authorDogan, Ozge Erol
dc.contributor.authorCelik, Kezban Esen Karaca
dc.contributor.authorBas, Murat
dc.contributor.authorAlan, Eyup Hakan
dc.contributor.authorCagin, Yasir Furkan
dc.date.accessioned2024-08-04T20:56:04Z
dc.date.available2024-08-04T20:56:04Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate the effects of the Mediterranean diet (MD), combined with curcumin and resveratrol supplementation, on disease activity, serum inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis (UC). This study was designed as a prospective multicenter three-arm randomized controlled trial. Participants were randomized to the MD, MD + curcumin, and MD + resveratrol groups. All participants were placed on the MD for 8 weeks. The MD + curcumin group also received 1600 mg/day of curcumin supplementation, whereas the MD + resveratrol group received 500 mg/day of resveratrol supplementation for 8 weeks. Anthropometric measurements, Truelove-Witts Index, Short Form-36, Inflammatory Bowel Disease Questionnaire, Mediterranean Diet Adherence Scale (MEDAS), and laboratory tests were performed at baseline and postintervention. Within-group comparisons showed that MD, MD + curcumin, and MD + resveratrol interventions were effective in reducing disease activity and inflammation and improving quality of life in individuals with UC (p < 0.05). Between-group comparisons revealed no significant difference in all parameters except for the pain subparameter of SF-36 and the MEDAS score (p < 0.05). The MD is an effective and safe intervention to be used in clinical practice in individuals with UC.en_US
dc.identifier.doi10.3390/nu16101504
dc.identifier.issn2072-6643
dc.identifier.issue10en_US
dc.identifier.pmid38794742en_US
dc.identifier.scopus2-s2.0-85194218886en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/nu16101504
dc.identifier.urihttps://hdl.handle.net/11616/102016
dc.identifier.volume16en_US
dc.identifier.wosWOS:001231684300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofNutrientsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectulcerative colitisen_US
dc.subjectMediterranean dieten_US
dc.subjectcurcuminen_US
dc.subjectresveratrolen_US
dc.subjectsupplementationen_US
dc.subjectinflammatory bowel diseasesen_US
dc.titleEffects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trialen_US
dc.typeArticleen_US

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