P50 sensory gating in children and adolescents with developmental stuttering
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Dosyalar
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Kekemelik seslerin, hecelerin ve kelimelerin istemsiz
tekran ve uzatilmasi ile konuima akiciliginin bozuldugu,
nedeni tarn olarak bilinmeyen bir konu^ma bozuklugudur.
Konuimanin akiciligjn saglanmasinda psikolojrk sosyal,
ögrenme ¡le ilt^kilí unsurlar ve sensorimotor degijkenler
önemli rol oynar. Beynin gelen uyanlari islemlemesinde ve
uygun bir davranissal yanit olujturulmasinda duyusal kapilama
gerekli bir ijlemdir. Duyusal kapilama, sinirli bi!gi ijleme
kapasitesine sahip olan beyni, siirekii ve yogun bilgi
akiii sirasmda gereginden fazia veya ili}kisiz olan uyaranlarin
filtrelenmesini saglayarak ajiri yüklenmeden korur. l^itsel
uyaranlann kapilanamamasi, i^itsel sinyallerin ijlenmesi
ve i^itsel geribildirim mekanizmasini da bozarak konujma
akiciliginm bozulmasina yol açabilir. Çalifmamizda kekemelikte
duyusal kapilamanin bozulmuj olabilecegi hipotezjni
test etmek i(;ir) gelijimsel kekemeligi olan çocuk ve ergenlerde
duyusal kapilamanin durumunu P50 supresyonu
ile degerlendirmeyi amaçladik.
Yöntem; Calijmaya gelisimsel kekemeligi oian 7-18 yaj
araliginda 20 çocuk ve etgen ile, konujma problemi olmayan
yaj ve cinsiyet açismdan birebir eíleítirilmi} 20 saglikli
kontrol alindi. Tüm olgulara bir çocuk psikiyatristi tarafindan
psikiyatrik degerlendirme yapildi. Psikiyatrik, nörolojik
ve kronik hastaligi olan, santral sinir sistemini etkileyen ilaç
kullanim öyküsü ve ailesinde sizofreni öykusü olan olgular
çalijma diji birakiidi. Tüm bu degerlendirmeierin ardindan
P 50 supresyon degerlendirmesi elektroensefologram
(EEG) ile kaydedildi. Cali^manin istatistiksel analizi SPSS paket
programi kullanilarak yapildi. Her iki grubun P50 degerlerini
kafiilajtifmak için Mann-Whitney U testi kuNanildi ve
tüm anaiizlerde p<0.05 anlamlilik derececesi olarak kabul
edildi.
Bulgular: Çalijmada yer alan çocuk ve ergenlerin yaj ortalamasi
11,8 ±2,7, kekemelik bajlama ya^i 4,6±1,1 idi. Çalijmaya
kalilanlann her iki grupta da 16'si |%80) erkek 4'ü (%
20) kizdi. Her iki grubun P50 amplitüt, latans, P50 supresyon
oranlari arasinda istatistiksel olarak anlamli fark saptanmadi.
Sonuç: Bu cali^manin sonuçlari çocuk ve ergenlerde P50 ile
kekemelik arasmda bir ili^ki olmadigmi ortaya koymaktadir.
Ancak kekeme çocuk ve ergenlerde duyusal kapilamayí degerlendiren
bu ilk çali^ma. duyusal kapilamayí degerlendirmede
kullanilan diger bir test oian prepulse inhibisyonla
da, farklt yaj gruplannda ve daha genij örneklem üzerinde
tekrarlanmalidir.
Objective: Stuttering is a speech disorder, where speech fluency is disturbed by the involuntary repetition and prolongation of words and syllables. Its cause is not fully known. Sensory gating is an essential part of information processing and developing an appropriate behavioral response in the brain. Psychological, social, and learningrelated factors together with sensorymotor variables play an important role in ensuring fluent speech. Sensory gating protects the brain from overload by filtering the redundant or potentially irrelevant information from the continuous and intensive stream of information. A lack of sensory gating for auditory stimuli may lead to disturbed auditory signal processing and auditory feedback and result in loss of speech fluency. Our aim in this study was to evaluate the state of sensory gating in children and adolescents with developmental stuttering using P50 suppression to test our hypothesis that sensory gating may be disturbed in stuttering. Method: A total of 20 stuttering children and adolescents in 7-18 age group and 20 age-and sex-matched healthy controis with no speech problems were included in the study. All children underwent psychiatric evaluation by a pédiatrie psychiatrist. Patients with psychiatric, neurological or chronic disease, those who had a history of using medication that could affect the central nervous system and children with a family history of schizophrenia were excluded from the study. P50 suppression was then recorded with an elearoencephalogram (EEG). Statistical analysis was performed using the SPSS package software program. The Mann-Whitney U test was used to compare the P50 values of the two groups and p value <0.05 was considered significant for all analyses. Results: The mean age for the children and adolescents included in the study was 11.8±2.7 years and the age stuttering started was 4.6±1.1 years. There were 16 males (80%) and 4 females (20%) in both groups. There was no statistically significant difference between the P50 amplitude, latency and P50 suppression ratios of the two groups. Conclusion: The results of this study have shown no association between P50 and stuttering in children and adolescents. However, this first study evaluating sensory gating in children and adolescents should be repeated with prepuise inhibition, another test used to evaluate sensory gating, on larger samples and in different age groups.
Objective: Stuttering is a speech disorder, where speech fluency is disturbed by the involuntary repetition and prolongation of words and syllables. Its cause is not fully known. Sensory gating is an essential part of information processing and developing an appropriate behavioral response in the brain. Psychological, social, and learningrelated factors together with sensorymotor variables play an important role in ensuring fluent speech. Sensory gating protects the brain from overload by filtering the redundant or potentially irrelevant information from the continuous and intensive stream of information. A lack of sensory gating for auditory stimuli may lead to disturbed auditory signal processing and auditory feedback and result in loss of speech fluency. Our aim in this study was to evaluate the state of sensory gating in children and adolescents with developmental stuttering using P50 suppression to test our hypothesis that sensory gating may be disturbed in stuttering. Method: A total of 20 stuttering children and adolescents in 7-18 age group and 20 age-and sex-matched healthy controis with no speech problems were included in the study. All children underwent psychiatric evaluation by a pédiatrie psychiatrist. Patients with psychiatric, neurological or chronic disease, those who had a history of using medication that could affect the central nervous system and children with a family history of schizophrenia were excluded from the study. P50 suppression was then recorded with an elearoencephalogram (EEG). Statistical analysis was performed using the SPSS package software program. The Mann-Whitney U test was used to compare the P50 values of the two groups and p value <0.05 was considered significant for all analyses. Results: The mean age for the children and adolescents included in the study was 11.8±2.7 years and the age stuttering started was 4.6±1.1 years. There were 16 males (80%) and 4 females (20%) in both groups. There was no statistically significant difference between the P50 amplitude, latency and P50 suppression ratios of the two groups. Conclusion: The results of this study have shown no association between P50 and stuttering in children and adolescents. However, this first study evaluating sensory gating in children and adolescents should be repeated with prepuise inhibition, another test used to evaluate sensory gating, on larger samples and in different age groups.
Açıklama
Anahtar Kelimeler
Kekemelik, Duyusal kapilama, P50, Stuttering, Sensory gating
Kaynak
BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
WoS Q Değeri
Scopus Q Değeri
Cilt
19
Sayı
3
Künye
Özcan, Ö. Altınayar, S. Özcan, A. Ünal, S. Karlıdağ, R. (2009). P50 sensory gating in children and adolescents with developmental stuttering. BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, 19(3), 241–246.
