Proton MR spectroscopy features of normal appearing white matter in neurofibromatosis type 1

Basit Öğe Kaydı
dc.authoridAslan, Mehmet/0000-0001-5710-6592
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridKutlu, Ramazan/0000-0001-7941-7025
dc.authorwosidSaraç, Kaya/ABI-1091-2020
dc.authorwosidAslan, Mehmet/AEL-7823-2022
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidKutlu, Ramazan/B-1624-2016
dc.contributor.authorAlkan, A
dc.contributor.authorSarac, K
dc.contributor.authorKutlu, R
dc.contributor.authorYakinci, C
dc.contributor.authorSigirci, A
dc.contributor.authorAslan, M
dc.contributor.authorOzcan, H
dc.date.accessioned2024-08-04T20:13:36Z
dc.date.available2024-08-04T20:13:36Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTo determine whether differences exist between neurofibromatosis type 1 (NF1) patients with or without focal lesions and healthy normal volunteers in the metabolite ratios of normal appearing white matter, 27 patients with NF1 (with parenchymal lesion, MR positive, n: 17; without parenchymal lesions, MR negative, n: 10) and 20 healthy volunteers underwent MRI and short TE (31 ms) proton MR spectroscopy (MRS). In 17 patients with parenchymal lesions, 61 focal lesions were detected by MRI. MRS was performed from normal appearing frontal and posterior parietal white matter (FWM and PWM) in NF1 and from control groups. NAA/Cr, Cho/Cr and MI/Cr ratios were calculated. Significant increase in Cho/Cr and MI/Cr ratios were found in FWM and PWM in MR negative and positive groups when compared to control group. NAA/Cr ratio in MR positive group was significantly decreased in FWM compared to control group. There were no significant differences between FWM and PWM in all metabolite ratios of MR negative group. MI/Cr ratio in MR positive group was significantly elevated in PWM compared to FWM. Metabolite changes detected by MRS could indicate demyelination and gliosis in normal appearing white matter in all NF1 patients, and additionally neuroaxonal damage in the FWM of NF1 patients with focal lesions. For that reason, in the clinical evaluation and follow-up of these patients MRS features of normal appearing white matter should be considered in addition to focal lesions. (C) 2003 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S0730-725X(03)00209-1
dc.identifier.endpage1053en_US
dc.identifier.issn0730-725X
dc.identifier.issn1873-5894
dc.identifier.issue9en_US
dc.identifier.pmid14684211en_US
dc.identifier.scopus2-s2.0-0348010231en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1049en_US
dc.identifier.urihttps://doi.org/10.1016/S0730-725X(03)00209-1
dc.identifier.urihttps://hdl.handle.net/11616/93723
dc.identifier.volume21en_US
dc.identifier.wosWOS:000187457100018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofMagnetic Resonance Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectneurofibromatosis type 1en_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectwhite matteren_US
dc.titleProton MR spectroscopy features of normal appearing white matter in neurofibromatosis type 1en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu