Characteristics of HCC Patients with Portal Vein Thrombosis: Albumin and Survival

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dc.contributor.authorCarr, Brian
dc.contributor.authorDonghia, Rossella
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2026-04-04T13:33:16Z
dc.date.available2026-04-04T13:33:16Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractIntroduction: Presence of macroscopic portal vein thrombosis (PVT) in patients with hepatocellular carcinoma (HCC) has been found to be a major poor prognosis characteristic. Aims: The aim of the study was to examine patients with PVT for their clinical characteristics and factors related to both PVT and survival. Methods: A large HCC database containing 1,094 patients with PVT and 2,513 patients without PVT was examined. Patients had routine baseline serum liver parameters and alpha-fetoprotein (AFP) levels measured, as well as radiological assessment of maximum tumor diameter (MTD), tumor number, presence of macroscopic PVT, plus survival. Results: The percent of patients with PVT increased with increase in both MTD and serum AFP levels and liver parameter levels were worse in patients with PVT than without it. A logistic regression model showed that the combination of MTD >5 cm plus AFP >100 IU/mL plus albumin <3.5 g/dL had an odds ratio of 10.988 for the presence of PVT. Normal serum albumin levels significantly reduced the hazard ratio for death in a Cox proportional hazard model and were associated with decreased liver failure. Conclusion: Logistic regression showed the significance of MTD, AFP, and albumin in the presence of PVT, and the Cox model highlighted the importance of albumin levels in decreasing death.
dc.description.sponsorshipNIH [CA 82723]
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723 (B.C.).
dc.identifier.doi10.1159/000542774
dc.identifier.endpage676
dc.identifier.issn0030-2414
dc.identifier.issn1423-0232
dc.identifier.issue8
dc.identifier.orcid0000-0002-6111-5077
dc.identifier.pmid39653023
dc.identifier.scopus2-s2.0-85214836313
dc.identifier.scopusqualityQ2
dc.identifier.startpage667
dc.identifier.urihttps://doi.org/10.1159/000542774
dc.identifier.urihttps://hdl.handle.net/11616/109052
dc.identifier.volume103
dc.identifier.wosWOS:001394279900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofOncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectHepatocellular carcinoma
dc.subjectPortal vein thrombosis
dc.subjectMultifocality
dc.subjectAlpha-fetoprotein
dc.subjectPlatelet-to-lymphocyte ratio
dc.subjectSurvival
dc.titleCharacteristics of HCC Patients with Portal Vein Thrombosis: Albumin and Survival
dc.typeArticle

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