Investigation the Cytotoxic and Antimicrobial Effect of Ranunculus Poluninii

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dc.contributor.authorMenevşe, İrem Nur
dc.contributor.authorTaşkın, Irmak İçen
dc.contributor.authorSancar, Pelin Yılmaz
dc.contributor.authorKürşat, Murat
dc.date.accessioned2024-08-04T19:42:51Z
dc.date.available2024-08-04T19:42:51Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRanunculus plant species, one of the endemic plants, are used in the treatment of various diseases such as febrile diseases, rheumatism and inflammatory rashes due to their pharmacological and toxicological activities. Considering these features, it was aimed to investigate the cytotoxic effects of Ranunculus poluninii on cancer cell lines, bacteria and yeasts. For this purpose, the extract of the plant was obtained by methanol extraction. Different concentrations of stock were prepared from this plant and applied to A549 and HCT116 cancer cell lines, and MTT assay was performed to determine cell viability. In addition, MIC values were determined by applying the prepared plant extract to Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, Candida albicans and Candida glabrata. Our results showed that Ranunculus poluninii was reduced cell viability to 83.7% at 100 µg/mL and 79% at 200 µg/mL on A549 and HCT116 respectively. In addition, it decreased both Candida albicans and Candida glabrata growth to 91.5% at 800 µg/m and 95.1% at 50 µg/mL respectively. Our results suggest that Ranunculus poluninii has anticancer effect and antifungal activity.en_US
dc.identifier.doi10.17798/bitlisfen.1403830
dc.identifier.endpage399en_US
dc.identifier.issn2147-3129
dc.identifier.issn2147-3188
dc.identifier.issue2en_US
dc.identifier.startpage393en_US
dc.identifier.trdizinid1245840en_US
dc.identifier.urihttps://doi.org/10.17798/bitlisfen.1403830
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1245840
dc.identifier.urihttps://hdl.handle.net/11616/88750
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofBitlis Eren Üniversitesi Fen Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation the Cytotoxic and Antimicrobial Effect of Ranunculus Poluniniien_US
dc.typeArticleen_US

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