Does cardiopulmonary bypass alter plasma level of tumor markers? CA 125 and carcinoembryonic antigen

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dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridErdil, Nevzat/0000-0002-8275-840X;
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidErdil, Nevzat/K-8079-2019
dc.authorwosidBattaloglu, Bektas/ABI-6211-2020
dc.contributor.authorBattaloglu, B
dc.contributor.authorKaya, E
dc.contributor.authorErdil, N
dc.contributor.authorNisanoglu, V
dc.contributor.authorKosar, F
dc.contributor.authorOzgur, B
dc.contributor.authorYildirim, B
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: In addition to malignant diseases, acute and chronic inflammations may elevate plasma levels of tumor markers CA 125 and carcinoembryonic antigen (CEA). Cardiopulmonary bypass (CPB) causes a generalized inflammatory response. In this study, we have investigated the effect of CPB on plasma levels of CA 125 and CEA. Methods: We measured plasma levels of CA 125 and CEA in patients undergoing coronary artery bypass grafting (CABG) with CPB (Group 1, n = 21), and in patients who underwent off-pump CABG, that is, without CPB (Group 2, n = 16). Blood samples were collected preoperatively, and on postoperative days 1, 6, and 12. Results: Within both groups, CEA plasma levels were not significantly influenced in any samples. Comparing with preoperative values, CA 125 values elevated significantly on postoperative days 6 and 12 within both groups. It was observed that the elevation of CA 125 plasma levels in these samples were significantly higher in Group 1. Conclusions: The results indicate that CPB elevated plasma level of CA 125. However, clinical importance of this finding needed further evaluation.en_US
dc.identifier.doi10.1055/s-2002-33102
dc.identifier.endpage203en_US
dc.identifier.issn0171-6425
dc.identifier.issn1439-1902
dc.identifier.issue4en_US
dc.identifier.pmid12165868en_US
dc.identifier.scopus2-s2.0-0036344944en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.1055/s-2002-33102
dc.identifier.urihttps://hdl.handle.net/11616/93405
dc.identifier.volume50en_US
dc.identifier.wosWOS:000177654300002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofThoracic and Cardiovascular Surgeonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcardiopulmonary bypassen_US
dc.subjecttumor markersen_US
dc.subjectcoronary artery bypass surgeryen_US
dc.titleDoes cardiopulmonary bypass alter plasma level of tumor markers? CA 125 and carcinoembryonic antigenen_US
dc.typeArticleen_US

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