The effect of long-term immunosuppressive therapy on gastrointestinal symptoms after kidney transplantation

dc.authoridGÜNEŞ, HÜSEYİN/0000-0001-5313-0819
dc.authoridSarıtaş, Serdar/0000-0003-4076-9001
dc.authorwosidGÜNEŞ, HÜSEYİN/GRJ-1595-2022
dc.authorwosidSarıtaş, Serdar/ABG-8413-2020
dc.contributor.authorBulbuloglu, Semra
dc.contributor.authorGunes, Huseyin
dc.contributor.authorSaritas, Serdar
dc.date.accessioned2024-08-04T20:50:55Z
dc.date.available2024-08-04T20:50:55Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We examined the relationship between compliance with long-term immunosuppressive therapy after kidney transplantation and gastrointestinal (GI) symptoms in patients discharged from hospitals in this study. Method: Our study was conducted as a descriptive study with the participation of 114 kidney transplant recipients discharged from the organ transplant center of a training and research hospital. Personal Information Form, Immunosuppressive Therapy Compliance Scale and Gastrointestinal Symptom Rating Scale were used in data collection. The data analysis was performed with IBM Statistical Package for the Social Sciences (SPSS) Statistics 25. Results: According to the findings, 47.4% of kidney transplant patients were between the ages of 46 and 64, and 80.7% of them were male. 41.2% of kidney recipients used immunosuppressive agents between 91 days and 6 months. Compliance with immunosuppressive therapy was similar in all age groups. It was determined that the recipients between the ages of 18 and 30 experienced GI symptoms the most. In terms of the predictors of GI symptoms, it was determined that mycophenolate mofetil (MMF) was effective in the development of reflux and diarrhoea, cyclosporine in the development of diarrhoea and constipation, and tacrolimus in the development of indigestion, which are (p < 0.05). Conclusion: For kidney recipients to have high compliance with immunosuppressive therapy, it is of great importance that they are able to cope with GI symptoms. Our study showed that GI symptoms increase in direct proportion as the duration of immunosuppressive therapy is prolonged and the level of compliance increases. GI symptoms of kidney transplant patients should be recognized, and recipients should be helped to manage those problems.en_US
dc.identifier.doi10.1016/j.trim.2021.101515
dc.identifier.issn0966-3274
dc.identifier.issn1878-5492
dc.identifier.pmid34922024en_US
dc.identifier.scopus2-s2.0-85121467513en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.trim.2021.101515
dc.identifier.urihttps://hdl.handle.net/11616/100371
dc.identifier.volume70en_US
dc.identifier.wosWOS:000746033900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTransplant Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastrointestinal symptomsen_US
dc.subjectImmunosuppressive agentsen_US
dc.subjectImmunosuppressive therapyen_US
dc.subjectLong-term immunosuppressionen_US
dc.subjectKidney transplantationen_US
dc.subjectRenal recipientsen_US
dc.titleThe effect of long-term immunosuppressive therapy on gastrointestinal symptoms after kidney transplantationen_US
dc.typeArticleen_US

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