Oxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitis

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dc.authoridAral, Kubra/0000-0003-4798-4548
dc.authoridAral, Cuneyt Asim/0000-0002-7366-345X
dc.authorwosidKapila, Yvonne/AAG-5418-2021
dc.authorwosidAral, Kubra/R-3039-2017
dc.authorwosidAral, Cüneyt Asım/ABG-8668-2020
dc.contributor.authorAral, Cuneyt Asim
dc.contributor.authorOlcer, Sude Nur
dc.contributor.authorAral, Kubra
dc.contributor.authorKapila, Yvonne
dc.date.accessioned2024-08-04T20:47:22Z
dc.date.available2024-08-04T20:47:22Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective The present study focused on investigating levels of oxidative stress, neutrophil elastase (NE), and insulin-like growth factor-binding protein 7 (IGFBP7) in oropharyngeal cancers (OC) with the presence and absence of periodontitis. Materials and Methods A healthy non-periodontitis group (H-NP; n = 20), a systemically healthy chronic periodontitis group (H-P; n = 20), a non-periodontitis group with OC (OC-NP; n = 12), and a chronic periodontitis group with OC (OC-P; n = 16) formed the study groups. The levels of NE and IGFBP7 were measured in gingival crevicular fluid (GCF) and saliva. In addition, oxidative status was determined by evaluating total oxidant status (TOS), total antioxidant status (TAS), and OSI (TOS/TAS). Results Gingival crevicular fluid NE was higher in all the groups compared with the H-NP group (p < .01). Salivary NE was higher in the OC-P and H-P groups compared with the H-NP and OC-NP groups (p < .05). Salivary IGFBP7 was significantly higher in the OC-NP and OC-P groups compared with the H-NP and H-P groups (p < .001). GCF TOS and OSI levels were significantly higher in all groups compared with the H-NP group (p < .05). Conclusions Gingival crevicular fluid NE levels were lower in healthy conditions compared with periodontal disease and OC. Salivary NE levels were higher in periodontal disease compared to states with no periodontal disease. Salivary IGFBP7 levels were higher in OC. Further analyses may help determine whether high salivary IGFBP7 levels distinguish OC from healthy conditions.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK), Ankara, Turkey [1919B011402711]en_US
dc.description.sponsorshipThe authors appreciate the financial support provided by The Scientific and Technological Research Council of Turkey (TUBITAK), Ankara, Turkey (Project #: 1919B011402711).en_US
dc.identifier.doi10.1111/odi.13370
dc.identifier.endpage1401en_US
dc.identifier.issn1354-523X
dc.identifier.issn1601-0825
dc.identifier.issue7en_US
dc.identifier.pmid32333474en_US
dc.identifier.scopus2-s2.0-85085562442en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1393en_US
dc.identifier.urihttps://doi.org/10.1111/odi.13370
dc.identifier.urihttps://hdl.handle.net/11616/99315
dc.identifier.volume26en_US
dc.identifier.wosWOS:000535486100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIGFBP7en_US
dc.subjectneutrophil elastaseen_US
dc.subjectoropharyngeal canceren_US
dc.subjectoxidative statusen_US
dc.subjectperiodontitisen_US
dc.titleOxidative stress, neutrophil elastase and IGFBP7 levels in patients with oropharyngeal cancer and chronic periodontitisen_US
dc.typeArticleen_US

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