Ultrastructural clues for glutamate-induced necrosis in parietal and cerebellar neurons

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dc.authoridEşrefoğlu, Mukaddes/0000-0003-3380-1480
dc.authorwosidEşrefoğlu, Mukaddes/JWA-4590-2024
dc.contributor.authorEsrefoglu, M
dc.contributor.authorGepdiremen, A
dc.contributor.authorKurus, M
dc.date.accessioned2024-08-04T20:13:18Z
dc.date.available2024-08-04T20:13:18Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractGlutamate excitotoxicity has been postulated to underlie the neuronal death that occurs after ischemia. The most sensitive tissues to ischemic injury are hippocampus and cerebellum, whereas cerebrum is more resistant. We studied the glutamate-induced ultrastructural alterations in rat parietal and cerebellar neurons comparatively. We observed that glutamate (45 min, 10(-7) M) causes considerable nuclear, mitochondrial and cytoplasmic changes in both the neuron types. Mitochondrial and nuclear changes were particularly more severe in cerebellar granular, than the ones in parietal neurons. It has been concluded that glutamate induces necrotic changes in both parietal and cerebellar neurons. But cerebellar cortex was found to be more sensitive to glutamate excitotoxicity than cerebral cortex. We suggest that mitochondrial damage is, probably, an important factor in neuron necrosis, which is mediated by glutamate excitotoxicity.en_US
dc.identifier.doi10.1046/j.1472-8206.2003.00149.x
dc.identifier.endpage347en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue3en_US
dc.identifier.pmid12803573en_US
dc.identifier.scopus2-s2.0-0037757865en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.1046/j.1472-8206.2003.00149.x
dc.identifier.urihttps://hdl.handle.net/11616/93530
dc.identifier.volume17en_US
dc.identifier.wosWOS:000183797800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcerebellumen_US
dc.subjectelectron microscopyen_US
dc.subjectexcitotoxicityen_US
dc.subjectnecrosisen_US
dc.subjectneocortexen_US
dc.subjectglutamateen_US
dc.titleUltrastructural clues for glutamate-induced necrosis in parietal and cerebellar neuronsen_US
dc.typeArticleen_US

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