The role of tuberculosis in COPD

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dc.authoridYakar, Halil Ibrahim/0000-0002-0973-9173
dc.authoridGunen, Hakan/0000-0001-6631-4457
dc.authoridPehlivan, Erkan/0000-0002-4361-3355
dc.authorwosidYakar, Halil Ibrahim/D-3870-2019
dc.authorwosidYakar, Halil Ibrahim/ABH-9459-2020
dc.authorwosidAydogan Eroglu, Selma/GWU-6454-2022
dc.authorwosidGunen, Hakan/HKV-9202-2023
dc.authorwosidPehlivan, Erkan/ABI-2115-2020
dc.contributor.authorYakar, Halil Ibrahim
dc.contributor.authorGunen, Hakan
dc.contributor.authorPehlivan, Erkan
dc.contributor.authorAydogan, Selma
dc.date.accessioned2024-08-04T20:42:55Z
dc.date.available2024-08-04T20:42:55Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Influence of tuberculosis (TB) on the natural course of COPD has not been well known. This study was designed to investigate the effects of history of TB on the long-term course of COPD. Methods: Patients hospitalized with COPD exacerbation were consecutively included (n=598). Cases were classified into two categories: those with TB history and those without. Clinical, demographic, and radiological features were meticulously recorded, and patients were followed up for hospitalizations due to exacerbation and for overall mortality. Results: A total of 93 patients (15%) had a history of TB. On average, patients with past TB history were 4 years younger than the rest of the patients (P=0.002). Our study revealed that patients with past TB were diagnosed with COPD 4 years earlier and died 5 years earlier as compared to the patients without TB. In addition, in the past TB group, rate of hospital admissions per year was higher compared to the group that lacked TB history (2.46 +/- 0.26 vs 1.56 +/- 0.88; P=0.001). Past TB group had higher arterial carbon dioxide tension (PaCO2) and lower forced expiratory volume in 1 second (FEV1; P=0.008 and P=0.069, respectively). Median survival was 24 months for patients who had past TB and 36 months for those who had not. Kaplan-Meier analysis revealed that although 3-year survival rate was lower in patients with past TB, it was not statistically significant (P=0.08). Cox regression analysis showed that while factors such as age, PaCO2, hematocrit, body mass index (BMI) and Charlson index affected mortality rates in COPD patients (P<0.05), prior history of TB did not. Conclusion: Our results showed that a history of TB caused more hospitalizations, reduced respiratory functions and increased PaCO2. It was found that, despite similarity of the overall mortality, COPD diagnosis and death occurred 5 years earlier in patients with past TB. We conclude that history of TB has an important role in the natural course of COPD.en_US
dc.identifier.doi10.2147/COPD.S116086
dc.identifier.endpage329en_US
dc.identifier.issn1178-2005
dc.identifier.pmid28176901en_US
dc.identifier.scopus2-s2.0-85010297266en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.2147/COPD.S116086
dc.identifier.urihttps://hdl.handle.net/11616/97672
dc.identifier.volume12en_US
dc.identifier.wosWOS:000392319400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofInternational Journal of Chronic Obstructive Pulmonary Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOPDen_US
dc.subjecttuberculosisen_US
dc.subjectmortalityen_US
dc.titleThe role of tuberculosis in COPDen_US
dc.typeArticleen_US

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