Hepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteria

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dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authoridcelikel, cigdem/0000-0002-9360-8116
dc.authoridYılmaz, Funda/0000-0003-1837-6498
dc.authoridNART, DENIZ/0000-0002-8100-6978
dc.authoridDeniz, Kemal/0000-0001-7749-2152
dc.authoridUmetsu, Sarah/0000-0003-2175-0671
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.authorwosidcelikel, cigdem/AAB-6540-2021
dc.authorwosidYılmaz, Funda/O-9646-2018
dc.authorwosidNART, DENIZ/KFS-5412-2024
dc.authorwosidAKYOL, Gulen/AHB-7455-2022
dc.contributor.authorDeniz, Kemal
dc.contributor.authorUmetsu, Sarah E.
dc.contributor.authorFerrell, Linda
dc.contributor.authorYilmaz, Funda
dc.contributor.authorGulluoglu, Mine
dc.contributor.authorSagol, Ozgul
dc.contributor.authorDogusoy, Gulen B.
dc.date.accessioned2024-08-04T20:49:28Z
dc.date.available2024-08-04T20:49:28Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims Hepatocellular adenoma (HCA) is an uncommon liver neoplasm, and studies of HCA subtypes have been primarily limited to France, the USA, and Japan. The aim of this study was to describe the clinicopathological features of HCA subtypes in Turkey. Methods and results The resection specimens of 59 cases diagnosed as 'hepatocellular adenoma' collected from 15 institutions were reviewed to confirm the diagnosis and to classify them according to the current World Health Organization 2019 classification. Immunostaining for glutamine synthetase, liver fatty acid-binding protein, C-reactive protein, beta-catenin and reticulin was performed. Of the 59 cases, 48 (81%) were diagnosed as HCA. We identified 24 (50%) hepatocyte nuclear factor 1 alpha (HNF1 alpha)-inactivated HCAs, five (10%) inflammatory HCAs, 15 (32%) beta-catenin-activated HCAs, three (6%) beta-catenin-activated inflammatory HCAs, and one (2%) unclassified HCA. HCA patients were predominantly female (female/male ratio of 5:1); they had a median age of 34 years and a median tumour diameter of 60 mm. In the beta-catenin-activated HCA group, nine cases (19%) showed cytoarchitectural atypia, and were also referred to as atypical hepatocellular neoplasms. In the beta-catenin-activated HCA group, three cases (6%) showed focal areas supportive of transition to HCA. The original diagnosis of HCA was changed to well-differentiated hepatocellular carcinoma in nine cases and to focal nodular hyperplasia in two cases. Conclusion In our series, the major HCA subtype was HNF1 alpha-inactivated HCA. We found a low incidence of inflammatory-type HCA. Our data also showed that beta-catenin-activated hepatocellular neoplasms, including cases with atypical histology, constituted a relatively high proportion of the cases. These findings are in contrast to those of most other studies of HCA subtypes.en_US
dc.identifier.doi10.1111/his.14330
dc.identifier.endpage33en_US
dc.identifier.issn0309-0167
dc.identifier.issn1365-2559
dc.identifier.issue1en_US
dc.identifier.pmid33406290en_US
dc.identifier.scopus2-s2.0-85104139736en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1111/his.14330
dc.identifier.urihttps://hdl.handle.net/11616/99881
dc.identifier.volume79en_US
dc.identifier.wosWOS:000639263200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofHistopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectatypical hepatocellular neoplasmen_US
dc.subjecthepatocellular adenomaen_US
dc.subjecthepatocellular carcinomaen_US
dc.titleHepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteriaen_US
dc.typeArticleen_US

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