Measurement of Strain Imaging, Troponin-I and Brain Natriuretic Peptide Levels in Radiotherapy-Induced Cardiac Injury

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dc.authoridÇakal, Sinem/0000-0003-2714-4584
dc.authoridÇakal, Beytullah/0000-0003-0230-6575;
dc.authorwosidÇakal, Beytullah/AAX-3708-2020
dc.authorwosidÇakal, Sinem/AAM-4396-2020
dc.authorwosidEkici, Kemal/AAF-6505-2022
dc.authorwosidÇakal, Beytullah/K-4789-2013
dc.authorwosidOmaygenc, Mehmet Onur/AAB-1610-2019
dc.authorwosidEkici, Kemal/AFJ-9488-2022
dc.contributor.authorEkici, Kemal
dc.contributor.authorCakal, Beytullah
dc.contributor.authorBaydar, Onur
dc.contributor.authorMayadagli, Alpaslan
dc.contributor.authorCakal, Sinem D.
dc.contributor.authorKaraca, Oguz
dc.contributor.authorOmaygenc, M. Onur
dc.date.accessioned2024-08-04T20:42:32Z
dc.date.available2024-08-04T20:42:32Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRadiotherapy (RT) of the thorax can damage the pericardium, myocardium, heart valves, and coronary vessels, with the pericardium being the most frequently damaged. The objectives of this study were to evaluate RT-induced left ventricular dysfunction and myocardial injury by measuring cardiac biomarkers, troponin I (TnI) and brain natriuretic peptide (BNP), as well as determin cardiotoxicity and early signs of cardiovascular dysfunction using strain rate imaging (SRI) prior to and following RT. This study included 35 patients diagnosed with thoracic malignancy between January 2011 and October 2013. Of the 35 patients, 22 had left-sided lung cancer and 13 had left-sided breast cancer. SRI was performed and TnI and BNP levels were measured prior to and following RT. A total radiation dose of 40-60 Gy (mean, 54.9 +/- 8.9 Gy) was applied in lung cancer patients and 50-60 Gy (mean, 51.6 +/- 4.9 Gy) was applied in breast cancer patients. No significant difference was observed in TnI or BNP levels prior to and one month following RT. The left ventricular ejection fraction (LVEF) did not differ prior to or after the first month of RT. However, lower right ventricular strain (RVS) and left ventricular strain (LVS) SRI values were detected within the first month following RT. From the results of this study, we conclude that SRI is a sensitive method to detect RT-induced changes in cardiac function that are not typically detected by conventional echocardiographic methods and cardiac biomarkers.en_US
dc.identifier.doi10.4999/uhod.161170
dc.identifier.endpage82en_US
dc.identifier.issn1306-133X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84979060341en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.4999/uhod.161170
dc.identifier.urihttps://hdl.handle.net/11616/97434
dc.identifier.volume26en_US
dc.identifier.wosWOS:000388274800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadiotherapyen_US
dc.subjectCardiac toxicityen_US
dc.subjectStrain rate imagingen_US
dc.subjectLeft-sided lung canceren_US
dc.subjectLeft ventricular ejection fractionen_US
dc.titleMeasurement of Strain Imaging, Troponin-I and Brain Natriuretic Peptide Levels in Radiotherapy-Induced Cardiac Injuryen_US
dc.typeArticleen_US

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