Beneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Study

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridKose, Evren/0000-0002-0246-2589
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidKose, Evren/ABG-9908-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.contributor.authorKose, Evren
dc.contributor.authorSapmaz, Hilal Irmak
dc.contributor.authorSarihan, Ediz
dc.contributor.authorVardi, Nigar
dc.contributor.authorTurkoz, Yusuf
dc.contributor.authorEkinci, Nihat
dc.date.accessioned2024-08-04T20:35:53Z
dc.date.available2024-08-04T20:35:53Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of montelukast against methotrexate-induced liver damage were investigated. 35 Wistar albino female rats were divided into 5 groups as follows: group I: control; group II: montelukast (ML); group III: methotrexate (Mtx); group IV: montelukast treatment after methotrexate application (Mtx + ML); group V: montelukast treatment before methotrexate application (ML + Mtx). At the end of the experiment, the liver tissues of rats were removed. Malondialdehyde (MDA), myeloperoxidase (MPO), and reduced glutathione levels were determined from liver tissues. In addition, the liver tissues were examined histologically. MDA and MPO levels of Mtx group were significantly increased when compared to control group. In Mtx + ML group, these parameters were decreased as compared to Mtx group. Mtx injection exhibited major histological alterations such as eosinophilic staining and swelling of hepatocytes. The glycogen storage in hepatocytes was observed as decreased by periodic acid schiff staining in Mtx group as compared to controls. ML treatment did not completely ameliorate the lesions and milder degenerative alterations as loss of the glycogen content was still present. It was showed that montelukast treatment after methotrexate application could reduce methotrexate-induced experimental liver damage.en_US
dc.identifier.doi10.1100/2012/987508
dc.identifier.issn1537-744X
dc.identifier.scopus2-s2.0-84861083157en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1100/2012/987508
dc.identifier.urihttps://hdl.handle.net/11616/95654
dc.identifier.wosWOS:000303256600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofScientific World Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectOrgan Injuryen_US
dc.subjectRat Modelen_US
dc.subjectAntioxidanten_US
dc.subjectCisplatinen_US
dc.subjectHepatocytesen_US
dc.subjectMelatoninen_US
dc.subjectProtectsen_US
dc.titleBeneficial Effects of Montelukast Against Methotrexate-Induced Liver Toxicity: A Biochemical and Histological Studyen_US
dc.typeArticleen_US

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