Spectrotemporal changes in electrical activity of myometrium due to recombinant follicle-stimulating hormone preparations follitropin alfa and beta

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dc.authoridTağluk, M. Emin/0000-0001-7789-6376
dc.authoridAYDIN, Nasuhi/0000-0003-3145-2432
dc.authorwosidAydin, Nasuhi E/B-6536-2012
dc.authorwosidTağluk, M. Emin/ABH-1005-2020
dc.authorwosidelter, koray/A-5082-2018
dc.authorwosidAYDIN, Nasuhi Engin/L-1607-2019
dc.authorwosidAYDIN, Nasuhi/O-9043-2016
dc.contributor.authorCelik, Onder
dc.contributor.authorTagluk, M. Emin
dc.contributor.authorHascalik, Seyma
dc.contributor.authorElter, Koray
dc.contributor.authorCelik, Nilufer
dc.contributor.authorAydin, Nasuhi Engin
dc.date.accessioned2024-08-04T20:30:59Z
dc.date.available2024-08-04T20:30:59Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the effects of follitropin alfa and beta on the myoelectrical activity of rat myometrium using signal-processing techniques. Design: Prospective, placebo-controlled study. Setting: Animal and pharmacology laboratory at Inonu University. Animal(S): Forty-five female Wistar albino rats. Intervention(s): Thirty of 45 animals involved in the experiment were registered as the superovulation group. After two successive normal estrous cycles, these animals were put into three equal subgroups. Group 1 was the control; animals were given 0.9% saline. Groups 2 and 3 were treated with follitropin alfa (Gonal-f) and follitropin beta (Puregon), respectively. The other 15 animals were ovariectomized (OVX) and subjected to the same protocol. The uterine myoelectrical signals were recorded and analyzed using a Matlab environment. Main Outcome Measure(s): Power/second, variance, and the effects of recombinant human follicle-stimulating hormone (FSH) on myoelectrical signals were assessed through temporal, spectral, and joint time-frequency analysis. The uterine endometrium and ovarian morphology were also assessed concerning primary follicles, antral follicles, and corpora lutea. Result(S): The power and some characteristic spectral components of myoelectrical signal were reduced with the administration of follitropin alfa and beta. No statistically significant difference was detected between endometrial and ovarian histology of the rats treated with these follitropins. Conclusion(s): Uterine myoelectrical signals change with administration of recombinant human FSH preparations. Follitropin beta and, more precisely, follitropin alfa suppress the spectral components and power of the myoelectrical signals, which provides uterine quiescence.en_US
dc.identifier.doi10.1016/j.fertnstert.2007.07.1391
dc.identifier.endpage1356en_US
dc.identifier.issn0015-0282
dc.identifier.pmid18068163en_US
dc.identifier.scopus2-s2.0-52949148178en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1348en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2007.07.1391
dc.identifier.urihttps://hdl.handle.net/11616/94657
dc.identifier.volume90en_US
dc.identifier.wosWOS:000259943600003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmyoelectrical signalen_US
dc.subjectfollitropin alfaen_US
dc.subjectfollitropin betaen_US
dc.subjectsuperovulationen_US
dc.subjectmyometriumen_US
dc.subjectendometriumen_US
dc.subjectraten_US
dc.titleSpectrotemporal changes in electrical activity of myometrium due to recombinant follicle-stimulating hormone preparations follitropin alfa and betaen_US
dc.typeArticleen_US

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