Synthesis and Investigation of Antimicrobial, Antioxidant, Enzymatic Inhibitory, and Antiproliferative Activities of Ruthenium (II) Complexes Bearing Benzimidazole-Based N-Heterocyclic Carbene (NHC) Ligands

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dc.authoridGurbuz, Nevin/0000-0003-3201-3597
dc.authorwosidMansour, Lamjed/AAD-8613-2019
dc.authorwosidGurbuz, Nevin/A-3069-2016
dc.contributor.authorHamdi, Naceur
dc.contributor.authorMansour, Lamjed
dc.contributor.authorAl-Tamimi, Jameel
dc.contributor.authorAl-Hazmy, Sadeq M.
dc.contributor.authorGurbuz, Nevin
dc.contributor.authorOzdemir, Ismail
dc.date.accessioned2024-08-04T20:53:22Z
dc.date.available2024-08-04T20:53:22Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe benzimidazolium salts 2a-d were synthesized by quaternization of 1-(4-tet-buthylbenzyl) benzimidazole, with the corresponding benzysl bromide. The reactions were carried out in dimethylformamide at 70 degrees C for 48 h. Therefore, Ag2O and benzimidazolium salts 2a-d were reacted in dichloromethane at room temperature under dark and Ag(I)-NHC complex 3 was obtained in very good yields. The Ru(II)-NHC complexes (4a-d) were synthesized via transmetalation reaction from 3a-d. The structures of the obtained compounds were characterized by different spectroscopic techniques such as H-1 and C-13 NMR, elemental analysis, and melting point detection. The lowest MICs values were obtained with the two complexes 4b and 4d. Enzymatic inhibitory investigation against acetylcholinesterase (AChE) and tyrosinase (TyrE), showed that the two complexes 4b and 4d are the most potent inhibitors against (AchE) with an IC50 of 2.52 and 5.06 mu g mL(-1) respectively, and against (TyrE) with an IC50 of 19.88 and 24.95 mu g mL(-1) respectively. Screening of the selected N-Heterocyclic carbene (NHC) ligands (2a-2d) and their respective ruthenium (II) complexes (4a-4d) against colon carcinoma cells lines (HCT-116) and hepatocellular carcinoma cells lines (HepG-2). Furthermore, compounds 2c, 2d, 4b were showed weak cytotoxic action with IC50 ranging from 13.38 to 18.33 mu g in human colon carcinoma cancer cell lines and from 14.36 to 18.45 mu g in hepatocellular carcinoma cells lines.en_US
dc.description.sponsorshipDeputyship for Research & Innovation, Ministry of Education and Qassim University, Saudi Arabia; [QU-IF-2-2-4-27178]en_US
dc.description.sponsorshipAcknowledgmentsThe authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education and Qassim University, Saudi Arabia for funding this research work through the project number (QU-IF-2-2-4-27178). The authors also thank to Qassim University for technical support.en_US
dc.identifier.doi10.1080/10406638.2022.2150659
dc.identifier.issn1040-6638
dc.identifier.issn1563-5333
dc.identifier.scopus2-s2.0-85146638707en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1080/10406638.2022.2150659
dc.identifier.urihttps://hdl.handle.net/11616/101125
dc.identifier.wosWOS:000910479300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPolycyclic Aromatic Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiological activityen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectbenzimidazolium saltsen_US
dc.subjectruthenium complexesen_US
dc.subjectHCT-116en_US
dc.subjectHepG-2en_US
dc.titleSynthesis and Investigation of Antimicrobial, Antioxidant, Enzymatic Inhibitory, and Antiproliferative Activities of Ruthenium (II) Complexes Bearing Benzimidazole-Based N-Heterocyclic Carbene (NHC) Ligandsen_US
dc.typeArticleen_US

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